Matches in SemOpenAlex for { <https://semopenalex.org/work/W2523133038> ?p ?o ?g. }
- W2523133038 endingPage "133" @default.
- W2523133038 startingPage "125" @default.
- W2523133038 abstract "The ventricular-subventricular zone (V-SVZ), which lies in the walls of the lateral ventricles (LV), is the largest neurogenic niche within the adult brain. Whether radiographic contact with the LV influences survival in glioblastoma (GBM) patients remains unclear. We assimilated and analyzed published data comparing survival in GBM patients with (LV+GBM) and without (LV-GBM) radiographic LV contact. PubMed, EMBASE, and Cochrane electronic databases were searched. Fifteen studies with survival data on LV+GBM and LV-GBM patients were identified. Their Kaplan-Meier survival curves were digitized and pooled for generation of median overall (OS) and progression free (PFS) survivals and log-rank hazard ratios (HRs). The log-rank and reported multivariate HRs after accounting for the common predictors of GBM survival were analyzed separately by meta-analyses. The calculated median survivals (months) from pooled data were 12.95 and 16.58 (OS), and 4.54 and 6.25 (PFS) for LV+GBMs and LV-GBMs, respectively, with an overall log-rank HRs of 1.335 [1.204-1.513] (OS) and 1.387 [1.225-1.602] (PFS). Meta-analysis of log-rank HRs resulted in summary HRs of 1.58 [1.35-1.85] (OS, 10 studies) and 1.41 [1.22-1.64] (PFS, 5 studies). Meta-analysis of multivariate HRs resulted in summary HRs of 1.35 [1.14-1.58] (OS, 6 studies) and 1.64 [0.88-3.05] (PFS, 3 studies). Patients with GBM contacting the LV have lower survival. This effect may be independent of the common predictors of GBM survival, suggesting a clinical influence of V-SVZ contact on GBM biology." @default.
- W2523133038 created "2016-09-30" @default.
- W2523133038 creator A5008154132 @default.
- W2523133038 creator A5044072248 @default.
- W2523133038 creator A5064815370 @default.
- W2523133038 creator A5070114395 @default.
- W2523133038 creator A5075018868 @default.
- W2523133038 creator A5078181843 @default.
- W2523133038 date "2016-09-19" @default.
- W2523133038 modified "2023-10-12" @default.
- W2523133038 title "Influence of glioblastoma contact with the lateral ventricle on survival: a meta-analysis" @default.
- W2523133038 cites W1551978591 @default.
- W2523133038 cites W1571698140 @default.
- W2523133038 cites W1767368847 @default.
- W2523133038 cites W1970451222 @default.
- W2523133038 cites W1971526515 @default.
- W2523133038 cites W1980441719 @default.
- W2523133038 cites W1982246823 @default.
- W2523133038 cites W1982967337 @default.
- W2523133038 cites W1989696297 @default.
- W2523133038 cites W1995194817 @default.
- W2523133038 cites W2006845009 @default.
- W2523133038 cites W2012253237 @default.
- W2523133038 cites W2012817412 @default.
- W2523133038 cites W2037044453 @default.
- W2523133038 cites W2045314069 @default.
- W2523133038 cites W2048690599 @default.
- W2523133038 cites W2053596462 @default.
- W2523133038 cites W2060475031 @default.
- W2523133038 cites W2060551076 @default.
- W2523133038 cites W2076043932 @default.
- W2523133038 cites W2078510083 @default.
- W2523133038 cites W2080964377 @default.
- W2523133038 cites W2093016929 @default.
- W2523133038 cites W2094838988 @default.
- W2523133038 cites W2095112467 @default.
- W2523133038 cites W2100958545 @default.
- W2523133038 cites W2103846082 @default.
- W2523133038 cites W2105284981 @default.
- W2523133038 cites W2105927926 @default.
- W2523133038 cites W2109107700 @default.
- W2523133038 cites W2109120242 @default.
- W2523133038 cites W2112236191 @default.
- W2523133038 cites W2113724387 @default.
- W2523133038 cites W2117577687 @default.
- W2523133038 cites W2119242698 @default.
- W2523133038 cites W2124736921 @default.
- W2523133038 cites W2138635257 @default.
- W2523133038 cites W2140165290 @default.
- W2523133038 cites W2156098321 @default.
- W2523133038 cites W2156330848 @default.
- W2523133038 cites W2157183936 @default.
- W2523133038 cites W2163807629 @default.
- W2523133038 cites W2165370359 @default.
- W2523133038 cites W2192451314 @default.
- W2523133038 cites W2414715655 @default.
- W2523133038 cites W246286872 @default.
- W2523133038 cites W366376508 @default.
- W2523133038 cites W4236153054 @default.
- W2523133038 cites W4294215472 @default.
- W2523133038 cites W832280635 @default.
- W2523133038 doi "https://doi.org/10.1007/s11060-016-2278-7" @default.
- W2523133038 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5262526" @default.
- W2523133038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27644688" @default.
- W2523133038 hasPublicationYear "2016" @default.
- W2523133038 type Work @default.
- W2523133038 sameAs 2523133038 @default.
- W2523133038 citedByCount "82" @default.
- W2523133038 countsByYear W25231330382016 @default.
- W2523133038 countsByYear W25231330382017 @default.
- W2523133038 countsByYear W25231330382018 @default.
- W2523133038 countsByYear W25231330382019 @default.
- W2523133038 countsByYear W25231330382020 @default.
- W2523133038 countsByYear W25231330382021 @default.
- W2523133038 countsByYear W25231330382022 @default.
- W2523133038 countsByYear W25231330382023 @default.
- W2523133038 crossrefType "journal-article" @default.
- W2523133038 hasAuthorship W2523133038A5008154132 @default.
- W2523133038 hasAuthorship W2523133038A5044072248 @default.
- W2523133038 hasAuthorship W2523133038A5064815370 @default.
- W2523133038 hasAuthorship W2523133038A5070114395 @default.
- W2523133038 hasAuthorship W2523133038A5075018868 @default.
- W2523133038 hasAuthorship W2523133038A5078181843 @default.
- W2523133038 hasBestOaLocation W25231330382 @default.
- W2523133038 hasConcept C10515644 @default.
- W2523133038 hasConcept C126322002 @default.
- W2523133038 hasConcept C143998085 @default.
- W2523133038 hasConcept C207103383 @default.
- W2523133038 hasConcept C2776194525 @default.
- W2523133038 hasConcept C2778921608 @default.
- W2523133038 hasConcept C2780739268 @default.
- W2523133038 hasConcept C3019894029 @default.
- W2523133038 hasConcept C38180746 @default.
- W2523133038 hasConcept C44249647 @default.
- W2523133038 hasConcept C502942594 @default.
- W2523133038 hasConcept C50382708 @default.
- W2523133038 hasConcept C66339696 @default.
- W2523133038 hasConcept C71924100 @default.