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- W2523137055 startingPage "385" @default.
- W2523137055 abstract "A series of rhodanine incorporated quinoline derivatives were efficiently synthesized using reusable DBU acetate as ionic liquid and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Ra (MTB) (ATCC 25177) and Mycobacterium bovis BCG (ATCC 35743) both in active and dormant state. Compounds 3e, 3f, 3g, 3h and 3i exhibited very good antitubercular activity. The active compounds were studied for cytotoxicity against HUVEC, THP-1, macrophages, A549, PANC-1 and HeLa cell lines using modified MTT assay and were found to be noncytotoxic. Inactivity of all these compounds against Gram positive and Gram negative bacteria indicates their specificity towards the MTB. Further, the synthesized compounds have been screened for their in vitro antifungal activity. In addition, the molecular docking studies revealed the binding modes of these compounds in active site of Zmp1 enzyme, which in turn helped to establish a structural basis of inhibition of mycobacteria. The results of present study clearly indicate the identification of some novel, selective and specific inhibitors against MTB that can be explored further for potential antitubercular drug." @default.
- W2523137055 created "2016-09-30" @default.
- W2523137055 creator A5001161450 @default.
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- W2523137055 creator A5049363259 @default.
- W2523137055 creator A5052530541 @default.
- W2523137055 creator A5060246769 @default.
- W2523137055 creator A5062524958 @default.
- W2523137055 creator A5065972327 @default.
- W2523137055 creator A5073530934 @default.
- W2523137055 date "2017-01-01" @default.
- W2523137055 modified "2023-10-17" @default.
- W2523137055 title "Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation" @default.
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