FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2523163024> ?p ?o ?g. }

• W2523163024 endingPage "1087" @default.
• W2523163024 startingPage "1082" @default.
• W2523163024 abstract "Recently, mutations in isocitrate dehydrogenase 1/2 (IDH1/2) were discovered in 70% of low-grade glioma and secondary glioblastoma multiforme. The discovery of an oncogenic function and the identification of onco-metabolites of IDH1/2 support new roles for metabolism in cancer. For example, some evidence indicates that IDH2 might also exhibit oncogenic functions by promoting cellular metabolism and cancer cell growth. We examined the association between IDH2 rs11540478 and lung cancer risk in 262 lung cancer patient cases and 602 healthy control subjects and also investigated the biological function of rs11540478 in vivo. We found that a higher risk was observed in lung cancer patient carriers of rs11540478 TT and CT compared with CC carriers (OR = 1.44; 95%CI = 1.04-2.00; P = 0.03). The frequency of IDH2 rs11540478 TT and CT carriers was decreased in healthy individuals between the ages of 50-77 compared to those aged 30-49 (OR = 0.67; 95%CI = 0.47-0.96; P = 0.03). Functional analysis showed the effect of rs11540478 on IDH2 expression and lung cancer cell viability, with higher IDH2 expression and cell viability among T allele compared with C allele. IDH2 mRNA was higher in peripheral blood lymphocytes from lung cancer patients compared to healthy subjects. Herein, for the first time we identified IDH2 rs11540478 as a new susceptibility locus for lung cancer. The effect of rs11540478 on mRNA expression of IDH2 and lung cancer cell viability might provide new insight for the genetic basis of lung cancer. © 2016 Wiley Periodicals, Inc." @default.
• W2523163024 created "2016-09-30" @default.
• W2523163024 creator A5004792206 @default.
• W2523163024 creator A5009017304 @default.
• W2523163024 creator A5013953750 @default.
• W2523163024 creator A5015630595 @default.
• W2523163024 creator A5025706886 @default.
• W2523163024 creator A5029734766 @default.
• W2523163024 creator A5033599365 @default.
• W2523163024 creator A5033649826 @default.
• W2523163024 creator A5035642288 @default.
• W2523163024 creator A5051769949 @default.
• W2523163024 creator A5061578883 @default.
• W2523163024 creator A5070778745 @default.
• W2523163024 creator A5071427686 @default.
• W2523163024 creator A5071437386 @default.
• W2523163024 date "2016-10-24" @default.
• W2523163024 modified "2023-09-23" @default.
• W2523163024 title "A new functional<i>IDH2</i>genetic variant is associated with the risk of lung cancer" @default.
• W2523163024 cites W1524255051 @default.
• W2523163024 cites W1525523952 @default.
• W2523163024 cites W1601247810 @default.
• W2523163024 cites W1972020976 @default.
• W2523163024 cites W1972039754 @default.
• W2523163024 cites W1991775451 @default.
• W2523163024 cites W1998248450 @default.
• W2523163024 cites W2007555374 @default.
• W2523163024 cites W2007846880 @default.
• W2523163024 cites W2008069197 @default.
• W2523163024 cites W2012379047 @default.
• W2523163024 cites W2023026302 @default.
• W2523163024 cites W2024055232 @default.
• W2523163024 cites W2025176940 @default.
• W2523163024 cites W2044055595 @default.
• W2523163024 cites W2056853053 @default.
• W2523163024 cites W2059903966 @default.
• W2523163024 cites W2063516289 @default.
• W2523163024 cites W2083707421 @default.
• W2523163024 cites W2093255090 @default.
• W2523163024 cites W2096796171 @default.
• W2523163024 cites W2101712284 @default.
• W2523163024 cites W2106787323 @default.
• W2523163024 cites W2118082971 @default.
• W2523163024 cites W2120240963 @default.
• W2523163024 cites W2121541480 @default.
• W2523163024 cites W2124236065 @default.
• W2523163024 cites W2126817554 @default.
• W2523163024 cites W2130764500 @default.
• W2523163024 cites W2132151898 @default.
• W2523163024 cites W2142597850 @default.
• W2523163024 cites W2149343603 @default.
• W2523163024 cites W2154193486 @default.
• W2523163024 cites W2222531233 @default.
• W2523163024 doi "https://doi.org/10.1002/mc.22573" @default.
• W2523163024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27649069" @default.
• W2523163024 hasPublicationYear "2016" @default.
• W2523163024 type Work @default.
• W2523163024 sameAs 2523163024 @default.
• W2523163024 citedByCount "7" @default.
• W2523163024 countsByYear W25231630242018 @default.
• W2523163024 countsByYear W25231630242019 @default.
• W2523163024 countsByYear W25231630242020 @default.
• W2523163024 countsByYear W25231630242022 @default.
• W2523163024 crossrefType "journal-article" @default.
• W2523163024 hasAuthorship W2523163024A5004792206 @default.
• W2523163024 hasAuthorship W2523163024A5009017304 @default.
• W2523163024 hasAuthorship W2523163024A5013953750 @default.
• W2523163024 hasAuthorship W2523163024A5015630595 @default.
• W2523163024 hasAuthorship W2523163024A5025706886 @default.
• W2523163024 hasAuthorship W2523163024A5029734766 @default.
• W2523163024 hasAuthorship W2523163024A5033599365 @default.
• W2523163024 hasAuthorship W2523163024A5033649826 @default.
• W2523163024 hasAuthorship W2523163024A5035642288 @default.
• W2523163024 hasAuthorship W2523163024A5051769949 @default.
• W2523163024 hasAuthorship W2523163024A5061578883 @default.
• W2523163024 hasAuthorship W2523163024A5070778745 @default.
• W2523163024 hasAuthorship W2523163024A5071427686 @default.
• W2523163024 hasAuthorship W2523163024A5071437386 @default.
• W2523163024 hasConcept C104317684 @default.
• W2523163024 hasConcept C121608353 @default.
• W2523163024 hasConcept C126322002 @default.
• W2523163024 hasConcept C127848430 @default.
• W2523163024 hasConcept C143998085 @default.
• W2523163024 hasConcept C180754005 @default.
• W2523163024 hasConcept C181199279 @default.
• W2523163024 hasConcept C2776059313 @default.
• W2523163024 hasConcept C2776256026 @default.
• W2523163024 hasConcept C2777150147 @default.
• W2523163024 hasConcept C501734568 @default.
• W2523163024 hasConcept C502942594 @default.
• W2523163024 hasConcept C54355233 @default.
• W2523163024 hasConcept C55493867 @default.
• W2523163024 hasConcept C71924100 @default.
• W2523163024 hasConcept C86803240 @default.
• W2523163024 hasConceptScore W2523163024C104317684 @default.
• W2523163024 hasConceptScore W2523163024C121608353 @default.
• W2523163024 hasConceptScore W2523163024C126322002 @default.
• W2523163024 hasConceptScore W2523163024C127848430 @default.

• next