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• W2523163679 endingPage "e1002560" @default.
• W2523163679 startingPage "e1002560" @default.
• W2523163679 abstract "The Slit protein is a major midline repellent for central nervous system (CNS) axons. In vivo, Slit is proteolytically cleaved into N- and C-terminal fragments, but the biological significance of this is unknown. Analysis in the Drosophila ventral nerve cord of a slit allele (slit-UC) that cannot be cleaved revealed that midline repulsion is still present but longitudinal axon guidance is disrupted, particularly across segment boundaries. Double mutants for the Slit receptors Dscam1 and robo1 strongly resemble the slit-UC phenotype, suggesting they cooperate in longitudinal axon guidance, and through biochemical approaches, we found that Dscam1 and Robo1 form a complex dependent on Slit-N. In contrast, Robo1 binding alone shows a preference for full-length Slit, whereas Dscam1 only binds Slit-N. Using a variety of transgenes, we demonstrated that Dscam1 appears to modify the output of Robo/Slit complexes so that signaling is no longer repulsive. Our data suggest that the complex is promoting longitudinal axon growth across the segment boundary. The ability of Dscam1 to modify the output of other receptors in a ligand-dependent fashion may be a general principle for Dscam proteins." @default.
• W2523163679 created "2016-09-30" @default.
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• W2523163679 date "2016-09-21" @default.
• W2523163679 modified "2023-10-12" @default.
• W2523163679 title "Dscam1 Forms a Complex with Robo1 and the N-Terminal Fragment of Slit to Promote the Growth of Longitudinal Axons" @default.
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• W2523163679 doi "https://doi.org/10.1371/journal.pbio.1002560" @default.
• W2523163679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5031454" @default.
• W2523163679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27654876" @default.
• W2523163679 hasPublicationYear "2016" @default.
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