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- W2523166424 abstract "Several studies in the literature suggest that the biotransformationof foreign compounds in man is more similar to that inthe non-human primate than to that in other laboratory animal species.However, published information about the pharmacokinetics of foreigncompounds in non-human primates is limited and usually derived fromone species, the rhesus monkey. In view of the often limited availabilityof this species for use in the development and safety evaluationof new drugs, pesticides, etc., it is necessary to search for potentialreplacement species for future use. This thesis compares the pharmacokineticsof seven well-known or commonly used drugs, i.e. antipyrine,diazepam, frusemide, ibuprofen, isosorbide dinitrate, paracetamol andpentobarbitone in the rhesus monkey, cynomolgus monkey and baboon witha view to defining further the suitability of these species for thestudy of newer substances. These three non-human primate species arethose that are most frequently used in pharmacology and toxicologystudies. The drugs were chosen for study because they are extensivelyused clinically and related human pharmacokinetic data are availablefor comparison. [Continues.]" @default.
- W2523166424 created "2016-09-30" @default.
- W2523166424 creator A5014102153 @default.
- W2523166424 date "1980-01-01" @default.
- W2523166424 modified "2023-09-27" @default.
- W2523166424 title "Comparative pharmacokinetics in non-human primates" @default.
- W2523166424 hasPublicationYear "1980" @default.
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