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• W2523169632 abstract "The role of vitamin D in calcium homeostasis and its impact on bone is well characterized and validated; however, the role vitamin D plays in non-bone physiology is less concrete. The Vitamin D Receptor (VDR) is expressed throughout the body and regulates many cellular processes. This discovery has led to vigorous research of vitamin D and the role it plays in many illnesses, especially those of high prevalence in the United States. Vitamin D deficiency has been implicated in numerous health conditions and thus is an intriguing target for therapeutic intervention. Studies examining the therapeutic effects of vitamin D in chronic disease and disease prevention have yielded conflicting results. Additionally, many publications on vitamin D result from studies in which vitamin D was not the primary focus. Given the increasing interest in the non-bone effects of vitamin D, we will review and summarize the recent literature related to older adults, a group with significantly increased risk of vitamin D deficiency. Older adults have substantial morbidity and mortality due to dementia, cancer and heart disease, all of which have been linked to vitamin D deficiency. We will explore current evidence of the expression of VDR and the effects of exposure to vitamin D that might impact these illnesses among older adults. We will review the most recent research on cognitive function and depression as a result of vitamin D deficiency. Through this work we aim to summarize the current data that sheds light on the possibility of clinical application of vitamin D therapy." @default.
• W2523169632 created "2016-09-30" @default.
• W2523169632 creator A5000651860 @default.
• W2523169632 creator A5064783372 @default.
• W2523169632 date "2014-01-01" @default.
• W2523169632 modified "2023-09-24" @default.
• W2523169632 title "Vitamin D in Aging and Chronic Illness" @default.
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• W2523169632 doi "https://doi.org/10.4172/vms.1000125" @default.
• W2523169632 hasPublicationYear "2014" @default.
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