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- W252317912 abstract "Kobeceram^[○!R](KC) has many characteristic advantages in chemical composition, shape, solubility behavior on the osteoconduction and stability of hydroxyapatite (HAP) granules, and is known to be useful for osteoplasty and dental implantation. In this paper mutagenicity and antigenicity of KC are described. A mutation test was carried out by observing reverse mutation with use of Salmonella typhimurium TA98 and TA100 strains, and 2-aminoanthracene was provided for positive control. Moreover, it was tried to develope active sensitization to KC and Sudan I, a positive control material, in guinea pigs by the adjuvant and patch test method. Then, neither mutagenicity nor skin sensitizing potential of KC was detected. From the above, it might be surmised that KC scarcely shows carcinogenicity and antigenicity in the humanbeings, even though much difficulty is pointed out in evaluating safety by extrapolation from bacterial or animal evidence." @default.
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- W252317912 date "1995-01-01" @default.
- W252317912 modified "2023-09-25" @default.
- W252317912 title "Mutagenicity and Antigenicity of a Newly Developed HAP Bioceramics, Kobeceram^[○!R]" @default.
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- W252317912 doi "https://doi.org/10.2504/kds.49.288" @default.
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