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- W2523186208 endingPage "932" @default.
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- W2523186208 abstract "Small-molecule inhibitors of tyrosine kinases (TKIs) are the mainstay of treatment for many malignancies and represent novel treatment options for other diseases such as idiopathic pulmonary fibrosis. Twenty-five TKIs are currently FDA-approved and >130 are being evaluated in clinical trials. Increasing evidence suggests that drug exposure of TKIs may significantly contribute to drug resistance, independently from somatic variation of TKI target genes. Membrane transport proteins may limit the amount of TKI reaching the target cells. This review highlights current knowledge on the basic and clinical pharmacology of membrane transporters involved in TKI disposition and their contribution to drug efficacy and adverse drug effects. In addition to non-genetic and epigenetic factors, genetic variants, particularly rare ones, in transporter genes are promising novel factors to explain interindividual variability in the response to TKI therapy." @default.
- W2523186208 created "2016-09-30" @default.
- W2523186208 creator A5010606351 @default.
- W2523186208 creator A5031324853 @default.
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- W2523186208 creator A5065181138 @default.
- W2523186208 creator A5065279964 @default.
- W2523186208 creator A5066057635 @default.
- W2523186208 date "2016-11-01" @default.
- W2523186208 modified "2023-09-23" @default.
- W2523186208 title "Impact of Membrane Drug Transporters on Resistance to Small-Molecule Tyrosine Kinase Inhibitors" @default.
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