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- W2523203805 endingPage "177" @default.
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- W2523203805 abstract "The first clinical trials of gene therapy in the 1990s offered the promise of a new paradigm for the treatment of genetic diseases. Over the decades that followed the challenges and setbacks which gene therapy faced often overshadowed any successes. Despite this, recent years have seen cause for renewed optimism. In 2012 Glybera™, an adeno-associated viral vector expressing lipoprotein lipase, became the first gene therapy product to receive marketing authorisation in Europe, with a licence to treat familial lipoprotein lipase deficiency. This followed the earlier licensing in China of two gene therapies: Gendicine™ for head and neck squamous cell carcinoma and Oncorine™ for late-stage nasopharyngeal cancer. By this stage over 1800 clinical trials had been, or were being, conducted worldwide, and the therapeutic targets had expanded far beyond purely genetic disorders. So far no trials of gene therapy have been carried out in pregnancy, but an increasing understanding of the molecular mechanisms underlying obstetric diseases means that it is likely to have a role to play in the future. This review will discuss how gene therapy works, its potential application in obstetric conditions and the risks and limitations associated with its use in this setting. It will also address the ethical and regulatory issues that will be faced by any potential clinical trial of gene therapy during pregnancy." @default.
- W2523203805 created "2016-09-30" @default.
- W2523203805 creator A5019394867 @default.
- W2523203805 creator A5070469242 @default.
- W2523203805 creator A5086727967 @default.
- W2523203805 date "2014-11-01" @default.
- W2523203805 modified "2023-09-23" @default.
- W2523203805 title "GENE THERAPY FOR OBSTETRIC CONDITIONS" @default.
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