Matches in SemOpenAlex for { <https://semopenalex.org/work/W2523335669> ?p ?o ?g. }
- W2523335669 endingPage "419" @default.
- W2523335669 startingPage "411" @default.
- W2523335669 abstract "Tauopathies are a hallmark of many neurodegenerative diseases, including Alzheimer's disease and traumatic brain injuries. It has been demonstrated that amyloid-beta peptides, alpha-synuclein, and prion proteins cross the blood-brain barrier (BBB), contributing to their abilities to induce disease. Very little is known about whether tau proteins can cross the BBB. Here we systematically characterized several key forms of tau proteins to cross the BBB, including Tau-441 (2N4R), Tau-410 (2N3R), truncated tau 151-391 (0N4R), and truncated tau 121-227. All of these tau proteins crossed the BBB readily and bidirectonally; however, only Tau-410 had a saturable component to its influx. The tau proteins also entered the blood after their injection into the brain, with Tau 121-227 having the slowest exit from brain. The tau proteins varied in regards to their enzymatic stability in brain and blood and in their peripheral pharmacokinetics. These results show that blood-borne tau proteins could contribute to brain tauopathies. The result also suggest that the CNS can contribute to blood levels of tau, raising the possibility that, as suggested for other misfolded proteins, blood levels of tau proteins could be used as a biomarker of CNS disease." @default.
- W2523335669 created "2016-09-30" @default.
- W2523335669 creator A5016122096 @default.
- W2523335669 creator A5049607612 @default.
- W2523335669 creator A5054959155 @default.
- W2523335669 creator A5072459478 @default.
- W2523335669 creator A5078844871 @default.
- W2523335669 creator A5090619468 @default.
- W2523335669 date "2016-11-01" @default.
- W2523335669 modified "2023-10-17" @default.
- W2523335669 title "Tau Proteins Cross the Blood-Brain Barrier" @default.
- W2523335669 cites W1139545554 @default.
- W2523335669 cites W1508243540 @default.
- W2523335669 cites W1540257283 @default.
- W2523335669 cites W1611407165 @default.
- W2523335669 cites W1744830941 @default.
- W2523335669 cites W1816716886 @default.
- W2523335669 cites W1971775491 @default.
- W2523335669 cites W1976490782 @default.
- W2523335669 cites W1985458075 @default.
- W2523335669 cites W1989005947 @default.
- W2523335669 cites W1997822484 @default.
- W2523335669 cites W2006642654 @default.
- W2523335669 cites W2011964677 @default.
- W2523335669 cites W2014627341 @default.
- W2523335669 cites W2018908557 @default.
- W2523335669 cites W2018910775 @default.
- W2523335669 cites W2020209643 @default.
- W2523335669 cites W2022195343 @default.
- W2523335669 cites W2024530340 @default.
- W2523335669 cites W2025944561 @default.
- W2523335669 cites W2027982151 @default.
- W2523335669 cites W2035345460 @default.
- W2523335669 cites W2035810650 @default.
- W2523335669 cites W2050041166 @default.
- W2523335669 cites W2059841300 @default.
- W2523335669 cites W2071384955 @default.
- W2523335669 cites W2077048957 @default.
- W2523335669 cites W2085646105 @default.
- W2523335669 cites W2090097368 @default.
- W2523335669 cites W2092078486 @default.
- W2523335669 cites W2111216320 @default.
- W2523335669 cites W2114185596 @default.
- W2523335669 cites W2116435444 @default.
- W2523335669 cites W2118608964 @default.
- W2523335669 cites W2142824097 @default.
- W2523335669 cites W2145440751 @default.
- W2523335669 cites W2154271806 @default.
- W2523335669 cites W2158118162 @default.
- W2523335669 cites W2222784460 @default.
- W2523335669 cites W2299280173 @default.
- W2523335669 cites W2398356848 @default.
- W2523335669 cites W2589731924 @default.
- W2523335669 cites W421486943 @default.
- W2523335669 doi "https://doi.org/10.3233/jad-160542" @default.
- W2523335669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27662303" @default.
- W2523335669 hasPublicationYear "2016" @default.
- W2523335669 type Work @default.
- W2523335669 sameAs 2523335669 @default.
- W2523335669 citedByCount "43" @default.
- W2523335669 countsByYear W25233356692017 @default.
- W2523335669 countsByYear W25233356692018 @default.
- W2523335669 countsByYear W25233356692019 @default.
- W2523335669 countsByYear W25233356692020 @default.
- W2523335669 countsByYear W25233356692021 @default.
- W2523335669 countsByYear W25233356692022 @default.
- W2523335669 countsByYear W25233356692023 @default.
- W2523335669 crossrefType "journal-article" @default.
- W2523335669 hasAuthorship W2523335669A5016122096 @default.
- W2523335669 hasAuthorship W2523335669A5049607612 @default.
- W2523335669 hasAuthorship W2523335669A5054959155 @default.
- W2523335669 hasAuthorship W2523335669A5072459478 @default.
- W2523335669 hasAuthorship W2523335669A5078844871 @default.
- W2523335669 hasAuthorship W2523335669A5090619468 @default.
- W2523335669 hasConcept C142724271 @default.
- W2523335669 hasConcept C169760540 @default.
- W2523335669 hasConcept C185592680 @default.
- W2523335669 hasConcept C2776156579 @default.
- W2523335669 hasConcept C2776925932 @default.
- W2523335669 hasConcept C2777739294 @default.
- W2523335669 hasConcept C2778402981 @default.
- W2523335669 hasConcept C2778670691 @default.
- W2523335669 hasConcept C2779134260 @default.
- W2523335669 hasConcept C502032728 @default.
- W2523335669 hasConcept C529278444 @default.
- W2523335669 hasConcept C71924100 @default.
- W2523335669 hasConcept C86803240 @default.
- W2523335669 hasConceptScore W2523335669C142724271 @default.
- W2523335669 hasConceptScore W2523335669C169760540 @default.
- W2523335669 hasConceptScore W2523335669C185592680 @default.
- W2523335669 hasConceptScore W2523335669C2776156579 @default.
- W2523335669 hasConceptScore W2523335669C2776925932 @default.
- W2523335669 hasConceptScore W2523335669C2777739294 @default.
- W2523335669 hasConceptScore W2523335669C2778402981 @default.
- W2523335669 hasConceptScore W2523335669C2778670691 @default.
- W2523335669 hasConceptScore W2523335669C2779134260 @default.
- W2523335669 hasConceptScore W2523335669C502032728 @default.
- W2523335669 hasConceptScore W2523335669C529278444 @default.