FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2523381777> ?p ?o ?g. }

• W2523381777 endingPage "1032" @default.
• W2523381777 startingPage "1025" @default.
• W2523381777 abstract "Prolactin (PRL) is a 23-kDa protein that can be synthesized and secreted by pituitary and extrapituitary tissues such as immune cells due to its expression being regulated by two independent promoter regions. The promoter which is responsible for extrapituitary expression contains the single nucleotide polymorphism (SNP) -1149 G/T previously associated with autoimmune diseases in various populations. This study evaluates the relationship of PRL -1149 G/T polymorphism with PRL serum levels and clinical characteristics in systemic lupus erythematosus (SLE) patients from western Mexico.One hundred and sixty-three SLE patients classified according to the 1982 American College of Rheumatology (ACR) SLE classification criteria and 326 unrelated control subjects (CS), both from western Mexico, were included. The PRL -1149 G/T polymorphism was genotyped using the polymerase chain reaction restriction fragment length polymorphism technique, and both PRL serum levels and autoantibodies were measured by enzyme-linked immunosorbent assay (ELISA).We found an association between the PRL -1149 TT genotype and SLE according to the recessive genetic model (OR = 2.26, 95% CI: 1.01-5.08, p = 0.04). The TT genotype was associated with anti-RNP antibodies (p = 0.04) and with higher scores of the Mex-SLEDAI (p = 0.02). Moreover, SLE patients showed elevated PRL serum levels (12.4 ng/ml; p < 0.01), and this condition was associated with renal activity and the presence of anti-RNP antibodies.PRL -1149 TT genotype is associated with susceptibility to SLE in a Mexican-Mestizo population, and high PRL serum levels are associated with anti-RNP antibodies and renal activity." @default.
• W2523381777 created "2016-09-30" @default.
• W2523381777 creator A5028521592 @default.
• W2523381777 creator A5029144136 @default.
• W2523381777 creator A5029462098 @default.
• W2523381777 creator A5034016883 @default.
• W2523381777 creator A5051494459 @default.
• W2523381777 creator A5054539295 @default.
• W2523381777 creator A5067876728 @default.
• W2523381777 creator A5077119751 @default.
• W2523381777 creator A5082688687 @default.
• W2523381777 creator A5088168825 @default.
• W2523381777 date "2018-01-01" @default.
• W2523381777 modified "2023-10-17" @default.
• W2523381777 title "Association of extrapituitary prolactin promoter polymorphism with disease susceptibility and anti-RNP antibodies in Mexican patients with systemic lupus erythematosus" @default.
• W2523381777 cites W1544490999 @default.
• W2523381777 cites W1901640178 @default.
• W2523381777 cites W1967326156 @default.
• W2523381777 cites W1974396376 @default.
• W2523381777 cites W1977549945 @default.
• W2523381777 cites W1983637269 @default.
• W2523381777 cites W1983927959 @default.
• W2523381777 cites W1985383230 @default.
• W2523381777 cites W2012277787 @default.
• W2523381777 cites W2015067566 @default.
• W2523381777 cites W2020209998 @default.
• W2523381777 cites W2036144540 @default.
• W2523381777 cites W2049628940 @default.
• W2523381777 cites W2061300556 @default.
• W2523381777 cites W2065153000 @default.
• W2523381777 cites W2067935052 @default.
• W2523381777 cites W2068090379 @default.
• W2523381777 cites W2070527591 @default.
• W2523381777 cites W2070537425 @default.
• W2523381777 cites W2076341611 @default.
• W2523381777 cites W2094153550 @default.
• W2523381777 cites W2097148421 @default.
• W2523381777 cites W2108905161 @default.
• W2523381777 cites W2112974239 @default.
• W2523381777 cites W2118094114 @default.
• W2523381777 cites W2123435698 @default.
• W2523381777 cites W2131802077 @default.
• W2523381777 cites W2134039034 @default.
• W2523381777 cites W2145966444 @default.
• W2523381777 cites W2151025663 @default.
• W2523381777 cites W2157116140 @default.
• W2523381777 cites W2168769379 @default.
• W2523381777 cites W2187917407 @default.
• W2523381777 cites W2369715615 @default.
• W2523381777 cites W2409158380 @default.
• W2523381777 cites W2414005975 @default.
• W2523381777 cites W2607741101 @default.
• W2523381777 cites W4292232933 @default.
• W2523381777 doi "https://doi.org/10.5114/aoms.2016.62138" @default.
• W2523381777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6111369" @default.
• W2523381777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30154884" @default.
• W2523381777 hasPublicationYear "2018" @default.
• W2523381777 type Work @default.
• W2523381777 sameAs 2523381777 @default.
• W2523381777 citedByCount "5" @default.
• W2523381777 countsByYear W25233817772019 @default.
• W2523381777 countsByYear W25233817772022 @default.
• W2523381777 countsByYear W25233817772023 @default.
• W2523381777 crossrefType "journal-article" @default.
• W2523381777 hasAuthorship W2523381777A5028521592 @default.
• W2523381777 hasAuthorship W2523381777A5029144136 @default.
• W2523381777 hasAuthorship W2523381777A5029462098 @default.
• W2523381777 hasAuthorship W2523381777A5034016883 @default.
• W2523381777 hasAuthorship W2523381777A5051494459 @default.
• W2523381777 hasAuthorship W2523381777A5054539295 @default.
• W2523381777 hasAuthorship W2523381777A5067876728 @default.
• W2523381777 hasAuthorship W2523381777A5077119751 @default.
• W2523381777 hasAuthorship W2523381777A5082688687 @default.
• W2523381777 hasAuthorship W2523381777A5088168825 @default.
• W2523381777 hasBestOaLocation W25233817771 @default.
• W2523381777 hasConcept C104317684 @default.
• W2523381777 hasConcept C126322002 @default.
• W2523381777 hasConcept C134018914 @default.
• W2523381777 hasConcept C135763542 @default.
• W2523381777 hasConcept C153209595 @default.
• W2523381777 hasConcept C159654299 @default.
• W2523381777 hasConcept C163764329 @default.
• W2523381777 hasConcept C198451711 @default.
• W2523381777 hasConcept C203014093 @default.
• W2523381777 hasConcept C2779064019 @default.
• W2523381777 hasConcept C2779075594 @default.
• W2523381777 hasConcept C54355233 @default.
• W2523381777 hasConcept C71315377 @default.
• W2523381777 hasConcept C71924100 @default.
• W2523381777 hasConcept C86803240 @default.
• W2523381777 hasConceptScore W2523381777C104317684 @default.
• W2523381777 hasConceptScore W2523381777C126322002 @default.
• W2523381777 hasConceptScore W2523381777C134018914 @default.
• W2523381777 hasConceptScore W2523381777C135763542 @default.
• W2523381777 hasConceptScore W2523381777C153209595 @default.
• W2523381777 hasConceptScore W2523381777C159654299 @default.
• W2523381777 hasConceptScore W2523381777C163764329 @default.
• W2523381777 hasConceptScore W2523381777C198451711 @default.

• next