Matches in SemOpenAlex for { <https://semopenalex.org/work/W2523492732> ?p ?o ?g. }
- W2523492732 abstract "Over-expression of TROP2 (the trophoblast cell surface antigen 2) was reported to predict poor prognosis in various solid tumors in number of studies. However, the results remained not comprehensive. Therefore, we here carried out this meta-analysis of relevant studies published on this topic to quantitatively evaluate the clinicopathological significance of TROP2 in solid tumors. Relevant articles were identified through searching the PubMed, Web of Science and Embase database. The primary outcomes were overall survival (OS) and disease-free survival (DFS). In this meta-analysis, 16 studies involving 2,569 participants were included, and we drew the conclusion that TROP2 overexpression was significantly associated with poor OS (pooled HR = 1.896, 95% CI = 1.599-2.247, P < 0.001) and short DFS (pooled HR = 2.336, 95% CI = 1.596-3.419, P < 0.001). Furthermore, the subgroup analysis revealed that the associations between TROP2 overexpression and the outcome endpoints (OS or DFS) were significant in in patients with female genital system neoplasms, as well in gastrointestine neoplasms. In addition, subgroup analysis found no difference HR across populations of different descent.Taken together, TROP2 overexpression was associated with poor survival in human solid tumors. TROP2 may be a valuable prognosis predictive biomarker and a potential therapeutic target in human solid tumors." @default.
- W2523492732 created "2016-09-30" @default.
- W2523492732 creator A5001891565 @default.
- W2523492732 creator A5010438328 @default.
- W2523492732 creator A5026782331 @default.
- W2523492732 creator A5070200464 @default.
- W2523492732 creator A5074387878 @default.
- W2523492732 creator A5085242699 @default.
- W2523492732 date "2016-09-20" @default.
- W2523492732 modified "2023-10-17" @default.
- W2523492732 title "Impact of TROP2 expression on prognosis in solid tumors: A Systematic Review and Meta-analysis" @default.
- W2523492732 cites W1975074702 @default.
- W2523492732 cites W1985566789 @default.
- W2523492732 cites W1990601892 @default.
- W2523492732 cites W1993127658 @default.
- W2523492732 cites W1995644316 @default.
- W2523492732 cites W2007872832 @default.
- W2523492732 cites W2010747774 @default.
- W2523492732 cites W2016267087 @default.
- W2523492732 cites W2026274236 @default.
- W2523492732 cites W2033585778 @default.
- W2523492732 cites W2039698731 @default.
- W2523492732 cites W2041969134 @default.
- W2523492732 cites W2043144595 @default.
- W2523492732 cites W2045306661 @default.
- W2523492732 cites W2049731781 @default.
- W2523492732 cites W2053900433 @default.
- W2523492732 cites W2088095316 @default.
- W2523492732 cites W2091994251 @default.
- W2523492732 cites W2093700012 @default.
- W2523492732 cites W2095432971 @default.
- W2523492732 cites W2107328434 @default.
- W2523492732 cites W2113922475 @default.
- W2523492732 cites W2116359274 @default.
- W2523492732 cites W2120920534 @default.
- W2523492732 cites W2122114596 @default.
- W2523492732 cites W2125435699 @default.
- W2523492732 cites W2128100381 @default.
- W2523492732 cites W2130697526 @default.
- W2523492732 cites W2141091746 @default.
- W2523492732 cites W2144763569 @default.
- W2523492732 cites W2157823046 @default.
- W2523492732 cites W2166845840 @default.
- W2523492732 cites W2232399331 @default.
- W2523492732 cites W2238400138 @default.
- W2523492732 cites W2398704602 @default.
- W2523492732 cites W2414783004 @default.
- W2523492732 doi "https://doi.org/10.1038/srep33658" @default.
- W2523492732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5028884" @default.
- W2523492732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27645103" @default.
- W2523492732 hasPublicationYear "2016" @default.
- W2523492732 type Work @default.
- W2523492732 sameAs 2523492732 @default.
- W2523492732 citedByCount "86" @default.
- W2523492732 countsByYear W25234927322017 @default.
- W2523492732 countsByYear W25234927322018 @default.
- W2523492732 countsByYear W25234927322019 @default.
- W2523492732 countsByYear W25234927322020 @default.
- W2523492732 countsByYear W25234927322021 @default.
- W2523492732 countsByYear W25234927322022 @default.
- W2523492732 countsByYear W25234927322023 @default.
- W2523492732 crossrefType "journal-article" @default.
- W2523492732 hasAuthorship W2523492732A5001891565 @default.
- W2523492732 hasAuthorship W2523492732A5010438328 @default.
- W2523492732 hasAuthorship W2523492732A5026782331 @default.
- W2523492732 hasAuthorship W2523492732A5070200464 @default.
- W2523492732 hasAuthorship W2523492732A5074387878 @default.
- W2523492732 hasAuthorship W2523492732A5085242699 @default.
- W2523492732 hasBestOaLocation W25234927321 @default.
- W2523492732 hasConcept C126322002 @default.
- W2523492732 hasConcept C143998085 @default.
- W2523492732 hasConcept C187960798 @default.
- W2523492732 hasConcept C2781197716 @default.
- W2523492732 hasConcept C3019894029 @default.
- W2523492732 hasConcept C3020774429 @default.
- W2523492732 hasConcept C55493867 @default.
- W2523492732 hasConcept C71924100 @default.
- W2523492732 hasConcept C86803240 @default.
- W2523492732 hasConcept C95190672 @default.
- W2523492732 hasConceptScore W2523492732C126322002 @default.
- W2523492732 hasConceptScore W2523492732C143998085 @default.
- W2523492732 hasConceptScore W2523492732C187960798 @default.
- W2523492732 hasConceptScore W2523492732C2781197716 @default.
- W2523492732 hasConceptScore W2523492732C3019894029 @default.
- W2523492732 hasConceptScore W2523492732C3020774429 @default.
- W2523492732 hasConceptScore W2523492732C55493867 @default.
- W2523492732 hasConceptScore W2523492732C71924100 @default.
- W2523492732 hasConceptScore W2523492732C86803240 @default.
- W2523492732 hasConceptScore W2523492732C95190672 @default.
- W2523492732 hasIssue "1" @default.
- W2523492732 hasLocation W25234927321 @default.
- W2523492732 hasLocation W25234927322 @default.
- W2523492732 hasLocation W25234927323 @default.
- W2523492732 hasLocation W25234927324 @default.
- W2523492732 hasOpenAccess W2523492732 @default.
- W2523492732 hasPrimaryLocation W25234927321 @default.
- W2523492732 hasRelatedWork W2092961885 @default.
- W2523492732 hasRelatedWork W2377377225 @default.
- W2523492732 hasRelatedWork W2396849083 @default.
- W2523492732 hasRelatedWork W2585787930 @default.