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- W2523598979 abstract "Anti-HIV-1 broadly neutralizing antibodies (bnAbs) have been extensively tested against pesudoviruses of diverse strains. We generated and characterized HIV-1 primary isolates from antiretroviral naïve infected Indian children, and determined their susceptibility to known NAbs. All the 8 isolates belonged to subtype-C and were R5 tropic. Majority of these viruses were resistant to neutralization by NAbs, suggesting that the bnAbs, known to efficiently neutralize pseudoviruses (adult and pediatric) of different strains, are less effective against pediatric primary isolates. Interestingly, AIIMS_329 isolate displayed high susceptibility to neutralization by PG9 and PG16bnAbs, with IC50 titer of 1.3 and 0.97μg/ml, suggesting exposure of this epitope on this virus. All isolates except AIIMS_506 were neutralized by contemporaneous plasma antibodies. Our findings suggest that primary isolates, due to close resemblance to viruses in natural infection, should be used to evaluate NAbs as effective vaccine candidates in both children and adults." @default.
- W2523598979 created "2016-09-30" @default.
- W2523598979 creator A5039572099 @default.
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- W2523598979 creator A5066574681 @default.
- W2523598979 creator A5079906976 @default.
- W2523598979 date "2016-12-01" @default.
- W2523598979 modified "2023-10-02" @default.
- W2523598979 title "Neutralization resistant HIV-1 primary isolates from antiretroviral naïve chronically infected children in India" @default.
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- W2523598979 doi "https://doi.org/10.1016/j.virol.2016.09.011" @default.
- W2523598979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27643887" @default.
- W2523598979 hasPublicationYear "2016" @default.
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