Matches in SemOpenAlex for { <https://semopenalex.org/work/W2523649430> ?p ?o ?g. }
- W2523649430 endingPage "3723" @default.
- W2523649430 startingPage "3712" @default.
- W2523649430 abstract "Targeted delivery of anticancer drugs to brain tumors, especially glioblastoma multiforme, which is the most frequent and aggressive type, is one of the important objectives in nanomedicine. Vascular endothelial growth factor (VEGF) and its receptor type II (VEGFR2) are promising targets because they are overexpressed by not only core tumor cells but also by migrated glioma cells, which are responsible for resistance and rapid progression of brain tumors. The purpose of the present study was to develop the liposomal drug delivery system combining enhanced loading capacity of cisplatin and high binding affinity to glioma cells. This was achieved by using of highly soluble cisplatin analogue, cis-diamminedinitratoplatinum(II), and antibodies against the native form of VEGF or VEGFR2 conjugated to liposome surface. The developed drug delivery system revealed sustained drug release profile, high affinity to antigens, and increased uptake by glioma C6 and U-87 MG cells. Pharmacokinetic study on glioma C6-bearing rats revealed prolonged blood circulation time of the liposomal formulation. The above features enabled the present drug delivery system to overcome both poor pharmacokinetics typical for platinum formulations and low loading capacity typical for conventional liposomal cisplatin formulations." @default.
- W2523649430 created "2016-09-30" @default.
- W2523649430 creator A5011781034 @default.
- W2523649430 creator A5012722075 @default.
- W2523649430 creator A5030242625 @default.
- W2523649430 creator A5046597724 @default.
- W2523649430 creator A5051845620 @default.
- W2523649430 creator A5052662655 @default.
- W2523649430 creator A5058574799 @default.
- W2523649430 creator A5060313302 @default.
- W2523649430 creator A5060362637 @default.
- W2523649430 creator A5064760094 @default.
- W2523649430 creator A5069914921 @default.
- W2523649430 creator A5075473071 @default.
- W2523649430 date "2016-10-03" @default.
- W2523649430 modified "2023-10-15" @default.
- W2523649430 title "VEGF- and VEGFR2-Targeted Liposomes for Cisplatin Delivery to Glioma Cells" @default.
- W2523649430 cites W1907795058 @default.
- W2523649430 cites W1966231387 @default.
- W2523649430 cites W1968568156 @default.
- W2523649430 cites W1977703960 @default.
- W2523649430 cites W1978002868 @default.
- W2523649430 cites W1986265466 @default.
- W2523649430 cites W1991032925 @default.
- W2523649430 cites W1994112854 @default.
- W2523649430 cites W1995340305 @default.
- W2523649430 cites W1998710000 @default.
- W2523649430 cites W2002516695 @default.
- W2523649430 cites W2003139134 @default.
- W2523649430 cites W2012182421 @default.
- W2523649430 cites W2015064273 @default.
- W2523649430 cites W2017928177 @default.
- W2523649430 cites W2018056548 @default.
- W2523649430 cites W2018486626 @default.
- W2523649430 cites W2018992636 @default.
- W2523649430 cites W2022305248 @default.
- W2523649430 cites W2050569993 @default.
- W2523649430 cites W2065829759 @default.
- W2523649430 cites W2068508373 @default.
- W2523649430 cites W2070167310 @default.
- W2523649430 cites W2070912023 @default.
- W2523649430 cites W2076200394 @default.
- W2523649430 cites W2078576156 @default.
- W2523649430 cites W2083856190 @default.
- W2523649430 cites W2090686331 @default.
- W2523649430 cites W2091455299 @default.
- W2523649430 cites W2091945030 @default.
- W2523649430 cites W2101539565 @default.
- W2523649430 cites W2105707498 @default.
- W2523649430 cites W2117267340 @default.
- W2523649430 cites W2122731269 @default.
- W2523649430 cites W2122757773 @default.
- W2523649430 cites W2130177169 @default.
- W2523649430 cites W2138151814 @default.
- W2523649430 cites W2154658129 @default.
- W2523649430 cites W2156969927 @default.
- W2523649430 cites W2161129035 @default.
- W2523649430 cites W4230970087 @default.
- W2523649430 doi "https://doi.org/10.1021/acs.molpharmaceut.6b00519" @default.
- W2523649430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27654150" @default.
- W2523649430 hasPublicationYear "2016" @default.
- W2523649430 type Work @default.
- W2523649430 sameAs 2523649430 @default.
- W2523649430 citedByCount "44" @default.
- W2523649430 countsByYear W25236494302016 @default.
- W2523649430 countsByYear W25236494302017 @default.
- W2523649430 countsByYear W25236494302018 @default.
- W2523649430 countsByYear W25236494302019 @default.
- W2523649430 countsByYear W25236494302020 @default.
- W2523649430 countsByYear W25236494302021 @default.
- W2523649430 countsByYear W25236494302022 @default.
- W2523649430 countsByYear W25236494302023 @default.
- W2523649430 crossrefType "journal-article" @default.
- W2523649430 hasAuthorship W2523649430A5011781034 @default.
- W2523649430 hasAuthorship W2523649430A5012722075 @default.
- W2523649430 hasAuthorship W2523649430A5030242625 @default.
- W2523649430 hasAuthorship W2523649430A5046597724 @default.
- W2523649430 hasAuthorship W2523649430A5051845620 @default.
- W2523649430 hasAuthorship W2523649430A5052662655 @default.
- W2523649430 hasAuthorship W2523649430A5058574799 @default.
- W2523649430 hasAuthorship W2523649430A5060313302 @default.
- W2523649430 hasAuthorship W2523649430A5060362637 @default.
- W2523649430 hasAuthorship W2523649430A5064760094 @default.
- W2523649430 hasAuthorship W2523649430A5069914921 @default.
- W2523649430 hasAuthorship W2523649430A5075473071 @default.
- W2523649430 hasConcept C112705442 @default.
- W2523649430 hasConcept C126322002 @default.
- W2523649430 hasConcept C167734588 @default.
- W2523649430 hasConcept C178790620 @default.
- W2523649430 hasConcept C185154212 @default.
- W2523649430 hasConcept C185592680 @default.
- W2523649430 hasConcept C2776694085 @default.
- W2523649430 hasConcept C2777025900 @default.
- W2523649430 hasConcept C2778227246 @default.
- W2523649430 hasConcept C2778239845 @default.
- W2523649430 hasConcept C2778402981 @default.
- W2523649430 hasConcept C2779820397 @default.
- W2523649430 hasConcept C2780035454 @default.