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- W2523653293 abstract "As stem cells contribute to the development and homeostasis of normal adult tissues, malfunction of stem cells in self-renewal and differentiation has been associated with tumorigenesis. A growing number of evidences indicating that tumor initiating cells play a crucial role, not only in malignancies, but also in generation and development of benign tumors. Here we offer an overview of the identification and functional characterization of benign tumor initiating cells in several tissues and organs, which typically show capacities of uncontrolled self-renewal to fuel the tumor growth and abnormal differentiation to give rise to tumor heterogeneity. They may originate from alteration of normal stem cells, which confer the benign tumor initiating cells with different repertoire of stemness. The plastic functions of benign tumor initiating cells are determined by niche regulation mediated via several signaling and epigenetic cues. Therefore, targeting stem cell function represents an important strategy for understanding the biology and management of benign tumors." @default.
- W2523653293 created "2016-09-30" @default.
- W2523653293 creator A5006713946 @default.
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- W2523653293 creator A5061550425 @default.
- W2523653293 creator A5084024908 @default.
- W2523653293 creator A5085230759 @default.
- W2523653293 date "2016-09-21" @default.
- W2523653293 modified "2023-09-27" @default.
- W2523653293 title "The role of stem cells in benign tumors" @default.
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- W2523653293 doi "https://doi.org/10.1007/s13277-016-5370-x" @default.
- W2523653293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27655284" @default.
- W2523653293 hasPublicationYear "2016" @default.
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