Matches in SemOpenAlex for { <https://semopenalex.org/work/W2523687130> ?p ?o ?g. }
- W2523687130 endingPage "e0163185" @default.
- W2523687130 startingPage "e0163185" @default.
- W2523687130 abstract "Psoriasis genetic background depends on polygenic and multifactorial mode of inheritance. As in other complex disorders, the estimation of the disease risk based on individual genetic variants is impossible. For this reason, recent investigations have been focused on combinations of known psoriasis susceptibility markers in order to improve the disease risk evaluation. Our aim was to compare psoriasis genetic risk score (GRS) for five susceptibility loci involved in the immunological response (HLA-C, ERAP1, ZAP70) and in the skin barrier function (LCE3, CSTA) between patients with chronic plaque psoriasis (n = 148) and the control group (n = 146). A significantly higher number of predisposing alleles was observed in patients with psoriasis in comparison to healthy individuals (6.1 vs. 5.2, respectively; P = 8.8×10−7). The statistical significance was even more profound when GRS weighted by logarithm odds ratios was evaluated (P = 9.9×10−14). Our results demonstrate the developed panel of five susceptibility loci to be more efficient in predicting psoriasis risk in the Polish population and to possess higher sensitivity and specificity for the disease than any of the markers analyzed separately, including the most informative HLA-C*06 allele." @default.
- W2523687130 created "2016-09-30" @default.
- W2523687130 creator A5016195926 @default.
- W2523687130 creator A5040056430 @default.
- W2523687130 creator A5043840109 @default.
- W2523687130 creator A5051547540 @default.
- W2523687130 creator A5056797754 @default.
- W2523687130 creator A5064101736 @default.
- W2523687130 creator A5067992257 @default.
- W2523687130 creator A5075353113 @default.
- W2523687130 creator A5084857406 @default.
- W2523687130 date "2016-09-22" @default.
- W2523687130 modified "2023-10-17" @default.
- W2523687130 title "Evaluation of Psoriasis Genetic Risk Based on Five Susceptibility Markers in a Population from Northern Poland" @default.
- W2523687130 cites W1795583523 @default.
- W2523687130 cites W1964651502 @default.
- W2523687130 cites W1966731757 @default.
- W2523687130 cites W1967937896 @default.
- W2523687130 cites W1970443682 @default.
- W2523687130 cites W1974388623 @default.
- W2523687130 cites W1981924240 @default.
- W2523687130 cites W1985841356 @default.
- W2523687130 cites W1989223663 @default.
- W2523687130 cites W1996765399 @default.
- W2523687130 cites W1997218603 @default.
- W2523687130 cites W1998551757 @default.
- W2523687130 cites W1998886148 @default.
- W2523687130 cites W2007805480 @default.
- W2523687130 cites W2014813076 @default.
- W2523687130 cites W2018623029 @default.
- W2523687130 cites W2020048539 @default.
- W2523687130 cites W2048011602 @default.
- W2523687130 cites W2049572499 @default.
- W2523687130 cites W2051610296 @default.
- W2523687130 cites W2060079989 @default.
- W2523687130 cites W2067724289 @default.
- W2523687130 cites W2075523083 @default.
- W2523687130 cites W2080713361 @default.
- W2523687130 cites W2087371579 @default.
- W2523687130 cites W2088400499 @default.
- W2523687130 cites W2093455167 @default.
- W2523687130 cites W2101359494 @default.
- W2523687130 cites W2105842551 @default.
- W2523687130 cites W2106686862 @default.
- W2523687130 cites W2124896761 @default.
- W2523687130 cites W2126532086 @default.
- W2523687130 cites W2128484342 @default.
- W2523687130 cites W2128847448 @default.
- W2523687130 cites W2130849049 @default.
- W2523687130 cites W2138048215 @default.
- W2523687130 cites W2144265655 @default.
- W2523687130 cites W2155570624 @default.
- W2523687130 cites W2163504863 @default.
- W2523687130 cites W2328176404 @default.
- W2523687130 doi "https://doi.org/10.1371/journal.pone.0163185" @default.
- W2523687130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5033405" @default.
- W2523687130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27658291" @default.
- W2523687130 hasPublicationYear "2016" @default.
- W2523687130 type Work @default.
- W2523687130 sameAs 2523687130 @default.
- W2523687130 citedByCount "13" @default.
- W2523687130 countsByYear W25236871302017 @default.
- W2523687130 countsByYear W25236871302018 @default.
- W2523687130 countsByYear W25236871302019 @default.
- W2523687130 countsByYear W25236871302020 @default.
- W2523687130 countsByYear W25236871302021 @default.
- W2523687130 countsByYear W25236871302022 @default.
- W2523687130 countsByYear W25236871302023 @default.
- W2523687130 crossrefType "journal-article" @default.
- W2523687130 hasAuthorship W2523687130A5016195926 @default.
- W2523687130 hasAuthorship W2523687130A5040056430 @default.
- W2523687130 hasAuthorship W2523687130A5043840109 @default.
- W2523687130 hasAuthorship W2523687130A5051547540 @default.
- W2523687130 hasAuthorship W2523687130A5056797754 @default.
- W2523687130 hasAuthorship W2523687130A5064101736 @default.
- W2523687130 hasAuthorship W2523687130A5067992257 @default.
- W2523687130 hasAuthorship W2523687130A5075353113 @default.
- W2523687130 hasAuthorship W2523687130A5084857406 @default.
- W2523687130 hasBestOaLocation W25236871301 @default.
- W2523687130 hasConcept C104317684 @default.
- W2523687130 hasConcept C126322002 @default.
- W2523687130 hasConcept C146304588 @default.
- W2523687130 hasConcept C147483822 @default.
- W2523687130 hasConcept C156957248 @default.
- W2523687130 hasConcept C180754005 @default.
- W2523687130 hasConcept C188280979 @default.
- W2523687130 hasConcept C203014093 @default.
- W2523687130 hasConcept C2779134260 @default.
- W2523687130 hasConcept C2780564577 @default.
- W2523687130 hasConcept C2908647359 @default.
- W2523687130 hasConcept C54355233 @default.
- W2523687130 hasConcept C67636389 @default.
- W2523687130 hasConcept C71924100 @default.
- W2523687130 hasConcept C86803240 @default.
- W2523687130 hasConcept C99454951 @default.
- W2523687130 hasConceptScore W2523687130C104317684 @default.
- W2523687130 hasConceptScore W2523687130C126322002 @default.
- W2523687130 hasConceptScore W2523687130C146304588 @default.