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- W2523698981 endingPage "5797" @default.
- W2523698981 startingPage "5780" @default.
- W2523698981 abstract "Signal transducer and activator of transcription 3 (STAT3) is aberrantly activated in glioblastoma and has been identified as a relevant therapeutic target in this disease and many other human cancers. After two decades of intensive research, there is not yet any approved STAT3-based glioma therapy. In addition to the canonical activation by tyrosine 705 phosphorylation, concordant reports described a potential therapeutic relevance of other post-translational modifications including mainly serine 727 phosphorylation. Such reports reinforce the need to refine the strategy of targeting STAT3 in each concerned disease. This review focuses on the role of serine 727 and tyrosine 705 phosphorylation of STAT3 in glioma. It explores their contribution to glial cell transformation and to the mechanisms that make glioma escape to both immune control and standard treatment." @default.
- W2523698981 created "2016-09-30" @default.
- W2523698981 creator A5002019326 @default.
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- W2523698981 creator A5048283999 @default.
- W2523698981 creator A5058168728 @default.
- W2523698981 creator A5066038764 @default.
- W2523698981 creator A5067174344 @default.
- W2523698981 date "2016-09-22" @default.
- W2523698981 modified "2023-10-18" @default.
- W2523698981 title "Role of STAT3 in Genesis and Progression of Human Malignant Gliomas" @default.
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