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- W2523737705 abstract "Objective Pharmacogenetic studies of fluoxetine in children and adolescents are scarce. After reporting the effect of genetic variants in genes related to the fluoxetine pharmacokinetics on clinical response in a pediatric population, we now evaluate the impact of genetic markers involved in its pharmacodynamics. Patients and methods The assessment was performed in 83 patients after 12 weeks of fluoxetine treatment. The genetic association analysis included a total of 316 validated single nucleotide polymorphisms in 45 candidate genes involved in six different pathways. Results Clinical improvement after treatment with fluoxetine in our pediatric population was associated significantly with two polymorphisms located in genes related to the serotonergic system: the 5-hydroxytryptamine receptor 1B (HTR1B) and the tryptophan 5-hydroxylase 2 (TPH2). Conclusion Although a wide range of candidate genes related to different pathways were assessed, the results show that genetic markers directly related to serotonin have an important effect on fluoxetine response." @default.
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- W2523737705 date "2016-11-01" @default.
- W2523737705 modified "2023-10-13" @default.
- W2523737705 title "Pharmacogenetic study focused on fluoxetine pharmacodynamics in children and adolescent patients" @default.
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- W2523737705 doi "https://doi.org/10.1097/fpc.0000000000000240" @default.
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