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- W2523848246 abstract "Abstract The back skin of C57 BL /6 mice was exposed to a single 400 mJ cm −2 dose of ultraviolet B ( UVB ), and parameters of hypothalamic–pituitary–adrenal ( HPA ) axis in relation to immune activity were tested after 30–90 min following irradiation. Levels of brain and/or plasma corticotropin‐releasing hormone ( CRH ), β ‐endorphin, ACTH and corticosterone ( CORT ) were enhanced by UVB . Hypophysectomy had no effect on UVB ‐induced increases of CORT . Mitogen‐induced IFN γ production by splenocytes from UVB ‐treated mice was inhibited at 30, 90 min and after 24 h. UVB also led to inhibition of IL ‐10 production indicating an immunosuppressive effect on both Th1 and Th2 cytokines. Conditioned media from splenocytes isolated from UVB ‐treated animals had no effect on IFN γ production in cultured normal splenocytes; however, IFN γ increased with conditioned media from sham‐irradiated animals. Sera from UVB ‐treated mice suppressed T‐cell mitogen‐induced IFN γ production as compared to sera from sham‐treated mice. IFN γ production was inhibited in splenocytes isolated from UVB ‐treated animals with intact pituitary, while stimulated in splenocytes from UVB ‐treated hypophysectomized mice. Thus, cutaneous exposure to UVB rapidly stimulates systemic CRH , ACTH , β ‐endorphin and CORT production accompanied by rapid immunosuppressive effects in splenocytes that appear to be independent of the HPA axis." @default.
- W2523848246 created "2016-10-07" @default.
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- W2523848246 date "2016-11-01" @default.
- W2523848246 modified "2023-10-17" @default.
- W2523848246 title "Skin Exposure to Ultraviolet B Rapidly Activates Systemic Neuroendocrine and Immunosuppressive Responses" @default.
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- W2523848246 doi "https://doi.org/10.1111/php.12642" @default.
- W2523848246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5366283" @default.
- W2523848246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27716949" @default.
- W2523848246 hasPublicationYear "2016" @default.
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