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• W2523869122 abstract "Intravenous use of a psychostimulant drug containing methcathinone (ephedrone) and manganese causes an irreversible extrapyramidal syndrome in drug abusers. We aimed to reproduce the syndrome in mice to evaluate dopaminergic damage. C57/B6 mice were intraperitoneally injected once a day with the study drug or saline for a period of 27 weeks. Motor activity was recorded in an automated motility-box. After 13 and 27 weeks of treatment, ex vivo digital autoradiography was performed using [11C]dihydrotetrabenazine ([11C]DTBZ). After 27 weeks of treatment [11C]DTBZ autoradiography demonstrated a significant increase in the striatum-to-cerebellum binding ratio compared with saline treated controls. At the same time point, there was no evident change in motor activity. Increased [11C]DTBZ binding may indicate vesicular monoamine transporter type 2 (VMAT2) function is altered. The lack of extrapyramidal symptoms in animals could be attributed to low dosing regimen or high metabolic rate." @default.
• W2523869122 created "2016-10-07" @default.
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• W2523869122 date "2016-12-01" @default.
• W2523869122 modified "2023-09-29" @default.
• W2523869122 title "Increased striatal VMAT2 binding in mice after chronic administration of methcathinone and manganese" @default.
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• W2523869122 doi "https://doi.org/10.1016/j.brainres.2016.09.034" @default.
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