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- W2523986989 abstract "目的 建立一种基于半胱氨酸偶联方式的抗体偶联药物（antibody-drug conjugates,ADCs）抗CD30-vc-MMAE异质性分析的质控方法。方法 本实验应用了分子排阻色谱（SEC-HPLC）、毛细管电泳（CE-SDS）以及实时成像毛细管等电聚焦电泳（i CIEF）等分析方法,对抗体偶联药物抗CD30-vc-MMAE的大小异质性和电荷异质性进行了分析。结果SEC-HPLC分析的纯度为（95.69±0.01）%;还原CE-SDS分析的纯度为（98.38±0.25）%,非还原CE-SDS可分离开6个主要峰,纯度之和为（97.82±0.44）%;和裸抗药物类似,i CIEF可有效的将酸区,碱区和主峰抗体进行较好地分离,主峰区的峰面积百分比为（43.52±2.03）%。结论 初步建立了一种基于半胱氨酸偶联方式的ADC药物抗CD30-vcMMAE异质性分析的质控方法 ,为此类生物制品的质量控制提供参考。" @default.
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- W2523986989 date "2016-01-01" @default.
- W2523986989 modified "2023-10-18" @default.
- W2523986989 title "抗体偶联药物抗CD30-vc-MMAE的异质性分析" @default.
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