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- W2524210387 abstract "T metabolic controlling cell hydration is a fundamental cellular parameter determining the functional activity of plasmatic membrane and intracellular macromolecules. The dysfunction of cGMP-dependent Na/Ca exchange in excitable cells has been suggested to underlie the ground of age-related cells dehydration, which leads to reducing of cell functional activity. To check this hypothesis the age-dependency of cell hydration, ouabain receptors affinity, Na/Ca exchange and +Na/+K pump activities, cAMP and cGMP intracellular contents as well as their chemoand magneto-sensitivity of rats’ brain and heart tissues were studied. The age-dependent depression of 3H-ouabain binding with high affinity receptors, the depression of Na/Ca exchange in forward mode and it’s activation in reverse mode, Na/K pump dysfunction, decrease of NOand SMF-induced elevation of intracellular cGMP content, tissue dehydration, and decrease of chemoand magneto-sensitivity of all the mentioned cell functional parameters were observed. The reciprocal relation in development between cGMP-dependent Na/Ca exchange in forward and cAMP-dependent Na/Ca exchange in reversal mode was shown: in young animals the Na/Ca exchange functioning in forward while in old animals-in reveres mode. Taking together the data obtained in the present work with earlier data obtained on snail isolated neurons and heart muscle, allows us to consider the aging-induced decrease of cell hydration, leading to age– related dysfunctions of different catabolic and anabolic metabolic pathways in cells as the consequence of the cGMP-dependent Na/Ca exchange dysfunction." @default.
- W2524210387 created "2016-10-07" @default.
- W2524210387 creator A5068118423 @default.
- W2524210387 date "2015-05-12" @default.
- W2524210387 modified "2023-09-26" @default.
- W2524210387 title "The dysfunction of cGMP-dependent Na/Ca exchange as a gate for age-related dysfunction of cellular activity" @default.
- W2524210387 hasPublicationYear "2015" @default.
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