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- W2524261111 abstract "It is understood that females and males with type 2 diabetes have normal or high bone mineral density (BMD), but limited studies in type 1 diabetes (T1D) suggest BMD deficits, mainly at the hip. We sought to characterize BMD in patients with longstanding T1D for ≥50 years. As part of ongoing deep-phenotyping procedures, 77 T1D participants were compared to 69 age- and gender-matched non-diabetic controls. BMD was measured by dual-energy X-ray absorptiometry; t-scores were determined for the lumbar spine (LS), total hip (TH) and femoral neck (FN). Weight, body mass index, biochemistry, insulin requirement, presence of complications and per cent fat mass were ascertained. Linear regression was used to compare BMD between T1D and controls, adjusted for confounders and stratified by sex. T1D participants had median diabetes duration 54 (52 to 59) years, 41(53%) were female and had mean t-scores of −0.4±1.4, −0.6±0.9 and −1.4±1.0 for LS, TH and FN, respectively. Controls had corresponding t-scores of −0.8±1.4, −0.5±1.0 and −1.1±0.9. In females, T1D had higher BMD at LS compared to controls (t-score −0.4±1.1 vs −1.1±1.4, p=0.015); there were no differences at TH or FN. In males, T1D had lower BMD at FN compared to controls (t-score −1.3±0.9 vs. −0.8±0.7, p=0.038); there were no differences at LS or TH. Differences persisted when adjusted for confounders for women, but the finding in men was confounded by per cent fat mass. Contrary to expectation, we observed no BMD deficit in longstanding T1D. Rather, we observed elevated BMD at the LS in women. Future research must identify factors influencing this sex-specific BMD pattern." @default.
- W2524261111 created "2016-10-07" @default.
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- W2524261111 date "2016-10-01" @default.
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- W2524261111 title "Bone Mineral Density in Patients with Longstanding Type 1 Diabetes: Results from the Canadian Study of Longevity in Diabetes" @default.
- W2524261111 doi "https://doi.org/10.1016/j.jcjd.2016.08.012" @default.
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