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- W2524492724 abstract "Endogenous Netrin-1 (NT-1) protein was significantly increased after cerebral ischemia, which may participate in the repair after transient cerebral ischemic injury. In this work, we explore whether NT-1 can be steadily overexpressed by AAV and the exogenous NT-1 can promote neural stem cells migration from the subventricular zone (SVZ) region after cerebral ischemia. Adult CD-1 mice were injected stereotacticly with adeno-associated virus carrying NT-1 gene (AAV-NT-1). Mice underwent 60 minutes of middle cerebral artery occlusion one week after injection. We found that NT-1 mainly expressed in neuron and astrocyte, and the expression level of NT-1 significantly increased one week after AAV-NT-1 gene transfer and lasted for 28 days, even after tMCAO as well (p＜0.05). Immunohistochemistry results showed that the number of neural stem cells was greatly increased in the SVZ region of AAV-NT-1-transduced mice compared with control mice. Our study showed that overexpressed NT-1 promoted neural stem cells migration from SVZ, this result suggested that NT-1 is a promising factor for repairing and remodeling after focal cerebral ischemia." @default.
- W2524492724 created "2016-10-07" @default.
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- W2524492724 date "2016-09-30" @default.
- W2524492724 modified "2023-10-18" @default.
- W2524492724 title "Hyperexpressed Netrin-1 Promoted Neural Stem Cells Migration in Mice after Focal Cerebral Ischemia" @default.
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- W2524492724 doi "https://doi.org/10.3389/fncel.2016.00223" @default.
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