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• W2524539178 startingPage "2869" @default.
• W2524539178 abstract "Deep brain stimulation of the internal globus pallidus (GPi) is a major treatment for advanced Parkinson's disease. The effects of this intervention on electrical activity patterns in targets of GPi output, specifically in the thalamus, are poorly understood. The experiments described here examined these effects using electrophysiological recordings in two Rhesus monkeys rendered moderately parkinsonian through treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), after sampling control data in the same animals. Analysis of spontaneous spiking activity of neurons in the basal ganglia-receiving areas of the ventral thalamus showed that MPTP-induced parkinsonism is associated with a reduction of firing rates of segments of the data that contained neither bursts nor decelerations, and with increased burst firing. Spectral analyses revealed an increase of power in the 3- to 13-Hz band and a reduction in the γ-range in the spiking activity of these neurons. Electrical stimulation of the ventrolateral motor territory of GPi with macroelectrodes, mimicking deep brain stimulation in parkinsonian patients (bipolar electrodes, 0.5 mm intercontact distance, biphasic stimuli, 120 Hz, 100 μs/phase, 200 μA), had antiparkinsonian effects. The stimulation markedly reduced oscillations in thalamic firing in the 13- to 30-Hz range and uncoupled the spiking activity of recorded neurons from simultaneously recorded local field potential (LFP) activity. These results confirm that oscillatory and nonoscillatory characteristics of spontaneous activity in the basal ganglia receiving ventral thalamus are altered in MPTP-induced parkinsonism. Electrical stimulation of GPi did not entrain thalamic activity but changed oscillatory activity in the ventral thalamus and altered the relationship between spikes and simultaneously recorded LFPs." @default.
• W2524539178 created "2016-10-07" @default.
• W2524539178 creator A5042569468 @default.
• W2524539178 creator A5044246558 @default.
• W2524539178 creator A5054293032 @default.
• W2524539178 creator A5081324356 @default.
• W2524539178 date "2016-12-01" @default.
• W2524539178 modified "2023-10-04" @default.
• W2524539178 title "Effects of high-frequency stimulation of the internal pallidal segment on neuronal activity in the thalamus in parkinsonian monkeys" @default.
• W2524539178 cites W1568832828 @default.
• W2524539178 cites W1589858513 @default.
• W2524539178 cites W1753238710 @default.
• W2524539178 cites W1872235122 @default.
• W2524539178 cites W1905563481 @default.
• W2524539178 cites W1964962588 @default.
• W2524539178 cites W1973275441 @default.
• W2524539178 cites W1974166127 @default.
• W2524539178 cites W1979699285 @default.
• W2524539178 cites W1979894237 @default.
• W2524539178 cites W1982060451 @default.
• W2524539178 cites W1987402221 @default.
• W2524539178 cites W1990454524 @default.
• W2524539178 cites W1993467197 @default.
• W2524539178 cites W1995798947 @default.
• W2524539178 cites W2001008031 @default.
• W2524539178 cites W2003209004 @default.
• W2524539178 cites W2008505701 @default.
• W2524539178 cites W2008686569 @default.
• W2524539178 cites W2009423181 @default.
• W2524539178 cites W2014154724 @default.
• W2524539178 cites W2014418774 @default.
• W2524539178 cites W2014598495 @default.
• W2524539178 cites W2017232032 @default.
• W2524539178 cites W2019896946 @default.
• W2524539178 cites W2021255671 @default.
• W2524539178 cites W2033771777 @default.
• W2524539178 cites W2036680608 @default.
• W2524539178 cites W2037125011 @default.
• W2524539178 cites W2041173453 @default.
• W2524539178 cites W2042660654 @default.
• W2524539178 cites W2043069334 @default.
• W2524539178 cites W2045526770 @default.
• W2524539178 cites W2051004303 @default.
• W2524539178 cites W2051867293 @default.
• W2524539178 cites W2056849177 @default.
• W2524539178 cites W2058126381 @default.
• W2524539178 cites W2060756235 @default.
• W2524539178 cites W2063564617 @default.
• W2524539178 cites W2063976700 @default.
• W2524539178 cites W2069444194 @default.
• W2524539178 cites W2072517893 @default.
• W2524539178 cites W2080570994 @default.
• W2524539178 cites W2083932518 @default.
• W2524539178 cites W2085073811 @default.
• W2524539178 cites W2089191479 @default.
• W2524539178 cites W2089209577 @default.
• W2524539178 cites W2089998624 @default.
• W2524539178 cites W2092310746 @default.
• W2524539178 cites W2092420754 @default.
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• W2524539178 cites W2102248966 @default.
• W2524539178 cites W2105383655 @default.
• W2524539178 cites W2119329187 @default.
• W2524539178 cites W2119520245 @default.
• W2524539178 cites W2121794462 @default.
• W2524539178 cites W2123208606 @default.
• W2524539178 cites W2125176389 @default.
• W2524539178 cites W2125469148 @default.
• W2524539178 cites W2126201966 @default.
• W2524539178 cites W2126696055 @default.
• W2524539178 cites W2127129065 @default.
• W2524539178 cites W2133177004 @default.
• W2524539178 cites W2141405085 @default.
• W2524539178 cites W2143662434 @default.
• W2524539178 cites W2145065776 @default.
• W2524539178 cites W2149924097 @default.
• W2524539178 cites W2150135821 @default.
• W2524539178 cites W2151111851 @default.
• W2524539178 cites W2167996685 @default.
• W2524539178 cites W2169621769 @default.
• W2524539178 cites W2169661540 @default.
• W2524539178 cites W2291665560 @default.
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• W2524539178 doi "https://doi.org/10.1152/jn.00104.2016" @default.
• W2524539178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5168000" @default.
• W2524539178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27683881" @default.
• W2524539178 hasPublicationYear "2016" @default.
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