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• W2524664830 endingPage "e1005897" @default.
• W2524664830 startingPage "e1005897" @default.
• W2524664830 abstract "To better characterize the behavior of HIV-1 capsids we developed EURT, for Entry/Uncoating assay based on core-packaged RNA availability and Translation. EURT is an alternative to Blam-Vpr, but as reporter RNA translation relies on core opening, it can be used to study viral capsids behavior. Our study reveals the existence of two major capsid species, a dead end one in which the viral genome is readily exposed to the cytoplasm and a functional one in which such exposure requires artificial core destabilization. Although reverse transcription drives a faster loss of susceptibility of viral cores to high doses of PF74, it does not lead to higher exposure of the viral genome, implying that viral cores protect the genome irrespectively of reverse transcription. Lastly, IFNα drifts cores from functional to non-functional species, revealing a novel core-destabilizing activity. This assay sheds new light on the behavior of viral cores inside target cells." @default.
• W2524664830 created "2016-10-07" @default.
• W2524664830 creator A5034237013 @default.
• W2524664830 creator A5085801818 @default.
• W2524664830 creator A5087318985 @default.
• W2524664830 date "2016-09-30" @default.
• W2524664830 modified "2023-09-23" @default.
• W2524664830 title "A Novel Entry/Uncoating Assay Reveals the Presence of at Least Two Species of Viral Capsids During Synchronized HIV-1 Infection" @default.
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• W2524664830 doi "https://doi.org/10.1371/journal.ppat.1005897" @default.
• W2524664830 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5045187" @default.
• W2524664830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27690375" @default.
• W2524664830 hasPublicationYear "2016" @default.
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