FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2524781036> ?p ?o ?g. }

• W2524781036 abstract "Lipid metabolism is essential for all major cell functions and has recently gained increasing attention in research and health studies. However, mathematical modeling by means of classical approaches such as stoichiometric networks and ordinary differential equation systems has not yet provided satisfactory insights, due to the complexity of lipid metabolism characterized by many different species with only slight differences and by promiscuous multifunctional enzymes. Here, we present a object-oriented stochastic model approach as a way to cope with the complex lipid metabolic network. While all lipid species are treated objects in the model, they can be modified by the respective converting reactions based on reaction rules, a hybrid method that integrates benefits of agent-based and classical stochastic simulation. This approach allows to follow the dynamics of all lipid species with different fatty acids, different degrees of saturation and different headgroups over time and to analyze the effect of parameter changes, potential mutations in the catalyzing enzymes or provision of different precursors. Applied to yeast metabolism during one cell cycle period, we could analyze the distribution of all lipids to the various membranes in time-dependent manner. The presented approach allows to efficiently treat the complexity of cellular lipid metabolism and to derive conclusions on the time- and location-dependent distributions of lipid species and their properties such as saturation. It is widely applicable, easily extendable and will provide further insights in healthy and diseased states of cell metabolism." @default.
• W2524781036 created "2016-10-07" @default.
• W2524781036 creator A5000058870 @default.
• W2524781036 creator A5003799374 @default.
• W2524781036 creator A5016157021 @default.
• W2524781036 creator A5058303812 @default.
• W2524781036 date "2016-09-27" @default.
• W2524781036 modified "2023-09-27" @default.
• W2524781036 title "Computational Modeling of Lipid Metabolism in Yeast" @default.
• W2524781036 cites W1807081515 @default.
• W2524781036 cites W1927096570 @default.
• W2524781036 cites W1984510004 @default.
• W2524781036 cites W1984954439 @default.
• W2524781036 cites W1985084275 @default.
• W2524781036 cites W1992233783 @default.
• W2524781036 cites W1995126993 @default.
• W2524781036 cites W1997664070 @default.
• W2524781036 cites W2003081219 @default.
• W2524781036 cites W2003310344 @default.
• W2524781036 cites W2004399350 @default.
• W2524781036 cites W2006111244 @default.
• W2524781036 cites W2011764708 @default.
• W2524781036 cites W2017163762 @default.
• W2524781036 cites W2018088831 @default.
• W2524781036 cites W2020972228 @default.
• W2524781036 cites W2028196283 @default.
• W2524781036 cites W2032087664 @default.
• W2524781036 cites W2039767442 @default.
• W2524781036 cites W2042321087 @default.
• W2524781036 cites W2044480313 @default.
• W2524781036 cites W2056728315 @default.
• W2524781036 cites W2066207556 @default.
• W2524781036 cites W2074554547 @default.
• W2524781036 cites W2074681199 @default.
• W2524781036 cites W2076164220 @default.
• W2524781036 cites W2077854212 @default.
• W2524781036 cites W2084924279 @default.
• W2524781036 cites W2088627521 @default.
• W2524781036 cites W2092838569 @default.
• W2524781036 cites W2093629098 @default.
• W2524781036 cites W2094489008 @default.
• W2524781036 cites W2101483263 @default.
• W2524781036 cites W2113442449 @default.
• W2524781036 cites W2116687544 @default.
• W2524781036 cites W2118686071 @default.
• W2524781036 cites W2128572161 @default.
• W2524781036 cites W2131525103 @default.
• W2524781036 cites W2134392026 @default.
• W2524781036 cites W2140718540 @default.
• W2524781036 cites W2150704630 @default.
• W2524781036 cites W2158075769 @default.
• W2524781036 cites W2160238206 @default.
• W2524781036 cites W2162471251 @default.
• W2524781036 cites W2163181319 @default.
• W2524781036 cites W2163182699 @default.
• W2524781036 cites W2170865437 @default.
• W2524781036 cites W2182883744 @default.
• W2524781036 cites W2406571591 @default.
• W2524781036 cites W4232275078 @default.
• W2524781036 cites W4239403073 @default.
• W2524781036 doi "https://doi.org/10.3389/fmolb.2016.00057" @default.
• W2524781036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5037213" @default.
• W2524781036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27730126" @default.
• W2524781036 hasPublicationYear "2016" @default.
• W2524781036 type Work @default.
• W2524781036 sameAs 2524781036 @default.
• W2524781036 citedByCount "9" @default.
• W2524781036 countsByYear W25247810362016 @default.
• W2524781036 countsByYear W25247810362018 @default.
• W2524781036 countsByYear W25247810362020 @default.
• W2524781036 countsByYear W25247810362021 @default.
• W2524781036 countsByYear W25247810362022 @default.
• W2524781036 countsByYear W25247810362023 @default.
• W2524781036 crossrefType "journal-article" @default.
• W2524781036 hasAuthorship W2524781036A5000058870 @default.
• W2524781036 hasAuthorship W2524781036A5003799374 @default.
• W2524781036 hasAuthorship W2524781036A5016157021 @default.
• W2524781036 hasAuthorship W2524781036A5058303812 @default.
• W2524781036 hasBestOaLocation W25247810361 @default.
• W2524781036 hasConcept C152662350 @default.
• W2524781036 hasConcept C186060115 @default.
• W2524781036 hasConcept C2777576037 @default.
• W2524781036 hasConcept C2779222958 @default.
• W2524781036 hasConcept C2984801823 @default.
• W2524781036 hasConcept C2991704936 @default.
• W2524781036 hasConcept C2994212657 @default.
• W2524781036 hasConcept C4733338 @default.
• W2524781036 hasConcept C55493867 @default.
• W2524781036 hasConcept C62231903 @default.
• W2524781036 hasConcept C70721500 @default.
• W2524781036 hasConcept C86803240 @default.
• W2524781036 hasConceptScore W2524781036C152662350 @default.
• W2524781036 hasConceptScore W2524781036C186060115 @default.
• W2524781036 hasConceptScore W2524781036C2777576037 @default.
• W2524781036 hasConceptScore W2524781036C2779222958 @default.
• W2524781036 hasConceptScore W2524781036C2984801823 @default.
• W2524781036 hasConceptScore W2524781036C2991704936 @default.
• W2524781036 hasConceptScore W2524781036C2994212657 @default.
• W2524781036 hasConceptScore W2524781036C4733338 @default.
• W2524781036 hasConceptScore W2524781036C55493867 @default.

• next