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- W2524869927 abstract "A collection of 1,2,3-triazoles unsaturated fatty acid mimics were efficiently synthesized by click chemistry. The 1,4-disubstituted analogs prepared covered different alkyl chain lengths and triazole positions. The compounds were subsequently tested against Mycobacterium tuberculosis, being most of them active with some of the analogs displaying activity at micromolar concentration. The most potent member of the series has the triazole moiety on the C-2 position with a carbon chain of eight or ten carbon atoms. The 1,5-isomers of the most active analog were significantly less active than the original isomer. The activity of the selected hit was assayed on several clinical MTB multi-drug resistant strains providing the same MIC." @default.
- W2524869927 created "2016-10-07" @default.
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- W2524869927 date "2017-01-01" @default.
- W2524869927 modified "2023-10-12" @default.
- W2524869927 title "Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives" @default.
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- W2524869927 doi "https://doi.org/10.1016/j.ejmech.2016.09.086" @default.
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