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- W2525068638 abstract "ABSTRACT Redox‐responsive core cross‐linked (CCL) micelles of poly(ethylene oxide)‐ b ‐poly(furfuryl methacrylate) (PEO‐ b ‐PFMA) block copolymers were prepared by the Diels‐Alder click‐type reaction. First, the PEO‐ b ‐PFMA amphiphilic block copolymer was synthesized by the reversible addition‐fragmentation chain transfer polymerization. The hydrophobic blocks of PFMA were employed to encapsulate the doxorubicin (DOX) drug, and they were cross‐linked using dithiobismaleimidoethane at 60 °C without any catalyst. Under physiological circumstance, the CCL micelles demonstrated the enhanced structural stability of the micelles, whereas dissociation of the micelles took place rapidly through the breaking of disulfide bonds in the cross‐linking linkages under reduction environment. The core‐cross‐linked micelles showed fine spherical distribution with hydrodynamic diameter of 68 ± 2.9 nm. The in vitro drug release profiles presented a slight release of DOX at pH 7.4, while a significant release of DOX was observed at pH 5.0 in the presence of 1,4‐dithiothreitol. MTT assays demonstrated that the block copolymer did not have any practically cytotoxicity against the normal HEK293 cell line while DOX‐loaded CCL micelles exhibited a high antitumor activity towards HepG2 cells. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016 , 54 , 3741–3750" @default.
- W2525068638 created "2016-10-07" @default.
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- W2525068638 date "2016-09-28" @default.
- W2525068638 modified "2023-10-16" @default.
- W2525068638 title "Redox-responsive core cross-linked micelles of poly(ethylene oxide)-<i>b</i> -poly(furfuryl methacrylate) by Diels-Alder reaction for doxorubicin release" @default.
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- W2525068638 doi "https://doi.org/10.1002/pola.28271" @default.
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