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- W2525223387 abstract "The purpose of this study was to evaluate the clinical significance of <sup>18</sup>F-FDG uptake by the spleen in patients with autoimmune disease. <b>Methods:</b> We retrospectively reviewed Severance Hospital’s electronic medical records of patients hospitalized for the evaluation of fever who underwent <sup>18</sup>F-FDG PET/CT. We found 91 patients with autoimmune diseases and 101 patients with localized infection. <sup>18</sup>F-FDG uptake was assessed by measuring SUV in the spleen and liver. The spleen-to-liver ratio of the SUV<sub>mean</sub> (SLR<sub>mean</sub>) was calculated. Clinical and laboratory parameters were collected and evaluated for association with SLR<sub>mean</sub>. In-hospital mortality was defined as all-cause mortality during hospital admission for fever. <b>Results:</b> SLR<sub>mean</sub> was significantly higher in autoimmune disease than in localized infectious disease (1.28 ± 0.43 vs. 0.91 ± 0.21, <i>P</i> < 0.001). In autoimmune disease, SLR<sub>mean</sub> was correlated with monocytes, aspartate aminotransferase, alanine aminotransferase, albumin, and ferritin. Analysis of receiver-operating-characteristic curves revealed that in comparison with laboratory parameters, SLR<sub>mean</sub> had the highest performance in differentiating autoimmune from localized infectious disease. Multivariate logistic regression analysis demonstrated that high SLR<sub>mean</sub> and low platelets were significantly associated with in-hospital mortality in febrile autoimmune disease. <b>Conclusion:</b> These findings suggest that spleen glucose metabolism is increased in febrile autoimmune disease. Spleen <sup>18</sup>F-FDG uptake may provide information useful in differentiating febrile autoimmune disease from localized infectious disease and predicting clinical outcomes in febrile autoimmune disease." @default.
- W2525223387 created "2016-10-07" @default.
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- W2525223387 date "2016-09-29" @default.
- W2525223387 modified "2023-10-16" @default.
- W2525223387 title "Evaluation of Spleen Glucose Metabolism Using <sup>18</sup>F-FDG PET/CT in Patients with Febrile Autoimmune Disease" @default.
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- W2525223387 doi "https://doi.org/10.2967/jnumed.116.180729" @default.
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