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- W2525362313 abstract "As bisphenol A (BPA) exerts oxidative/pro-apoptotic effects in several cell types, we explored whether the in vitro exposure to BPA could affect human sperm integrity through the induction of pro-oxidative/apoptotic mitochondrial dysfunction. The exposure of motile sperm suspensions to scalar BPA concentrations for 4h produced a decrease in the mitochondrial membrane potential, starting from 300μM. It was associated with an increased mitochondrial generation of superoxide anion, caspase-9 and caspase-3 activation and motility decrement. Vitality decline was observed at BPA≥400μM. Twenty hours exposure to 300μM BPA, but not to lower concentrations, produced a significant loss in sperm vitality associated with a complete sperm immobilization. Finally, 300μM BPA also produced a significant DNA oxidative damage, as revealed by the formation of oxidized base adduct 8-hydroxy-2'-deoxyguanosine. In conclusion, BPA affected human sperm integrity by inducing pro-oxidative/apoptotic mitochondrial dysfunction." @default.
- W2525362313 created "2016-10-07" @default.
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- W2525362313 date "2016-12-01" @default.
- W2525362313 modified "2023-10-14" @default.
- W2525362313 title "In vitro exposure of human spermatozoa to bisphenol A induces pro-oxidative/apoptotic mitochondrial dysfunction" @default.
- W2525362313 cites W1508186720 @default.
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- W2525362313 cites W1950408523 @default.
- W2525362313 cites W1967211742 @default.
- W2525362313 cites W1970358298 @default.
- W2525362313 cites W1975204728 @default.
- W2525362313 cites W1978240533 @default.
- W2525362313 cites W1980969730 @default.
- W2525362313 cites W1983667216 @default.
- W2525362313 cites W1984883568 @default.
- W2525362313 cites W1986951035 @default.
- W2525362313 cites W1988194549 @default.
- W2525362313 cites W1988353980 @default.
- W2525362313 cites W1989924212 @default.
- W2525362313 cites W1991626426 @default.
- W2525362313 cites W1994413221 @default.
- W2525362313 cites W1998705425 @default.
- W2525362313 cites W2002208801 @default.
- W2525362313 cites W2008366199 @default.
- W2525362313 cites W2008583150 @default.
- W2525362313 cites W2014585392 @default.
- W2525362313 cites W2014754613 @default.
- W2525362313 cites W2015028096 @default.
- W2525362313 cites W2017619625 @default.
- W2525362313 cites W2020338693 @default.
- W2525362313 cites W2024866328 @default.
- W2525362313 cites W2025177218 @default.
- W2525362313 cites W2031786223 @default.
- W2525362313 cites W2033211255 @default.
- W2525362313 cites W2035824032 @default.
- W2525362313 cites W2036238275 @default.
- W2525362313 cites W2037728383 @default.
- W2525362313 cites W2040970938 @default.
- W2525362313 cites W2041124206 @default.
- W2525362313 cites W2043319761 @default.
- W2525362313 cites W2044745267 @default.
- W2525362313 cites W2044972099 @default.
- W2525362313 cites W2045344984 @default.
- W2525362313 cites W2046315822 @default.
- W2525362313 cites W2049240688 @default.
- W2525362313 cites W2054446926 @default.
- W2525362313 cites W2057598257 @default.
- W2525362313 cites W2059392150 @default.
- W2525362313 cites W2060803234 @default.
- W2525362313 cites W2064391541 @default.
- W2525362313 cites W2064692473 @default.
- W2525362313 cites W2066252864 @default.
- W2525362313 cites W2067194217 @default.
- W2525362313 cites W2071850731 @default.
- W2525362313 cites W2072345180 @default.
- W2525362313 cites W2076104235 @default.
- W2525362313 cites W2078532276 @default.
- W2525362313 cites W2078764376 @default.
- W2525362313 cites W2090601295 @default.
- W2525362313 cites W2091345387 @default.
- W2525362313 cites W2095051171 @default.
- W2525362313 cites W2097111186 @default.
- W2525362313 cites W2108900261 @default.
- W2525362313 cites W2109879710 @default.
- W2525362313 cites W2114729638 @default.
- W2525362313 cites W2123298581 @default.
- W2525362313 cites W2132624353 @default.
- W2525362313 cites W2138484830 @default.
- W2525362313 cites W2140367523 @default.
- W2525362313 cites W2157029495 @default.
- W2525362313 cites W2158173525 @default.
- W2525362313 cites W2158303874 @default.
- W2525362313 cites W2170523452 @default.
- W2525362313 cites W2252652140 @default.
- W2525362313 cites W2300532815 @default.
- W2525362313 cites W2345911720 @default.
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- W2525362313 doi "https://doi.org/10.1016/j.reprotox.2016.09.014" @default.
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- W2525362313 hasPublicationYear "2016" @default.
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