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- W2525555311 abstract "Due to the key role in various cellular processes including cell proliferation and cell survival on many cell types, dysregulation of the PI3K/AKT pathway represents a crucial step of the pathogenesis in many diseases. Furthermore, the tumor suppressor PTEN negatively regulates the PI3K/AKT pathway through its lipid phosphatase activity, which is recognized as one of the most frequently deleted and/or mutated genes in human cancer. Given the pervasive involvement of this pathway, the development of the molecules that modulate this PI3K/AKT signaling has been initiated in studies which focus on the extensive effective drug discovery. Consequently, the PI3K/AKT pathway appears to be an attractive pharmacological target both for cancer therapy and for neurological protection necessary after the therapy. A better understanding of the molecular relations could reveal new targets for treatment development. We review recent studies on the features of PI3K/AKT and PTEN, and their pleiotropic functions relevant to the signaling pathways involved in cancer progress and in neuronal damage by the therapy." @default.
- W2525555311 created "2016-10-07" @default.
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- W2525555311 date "2016-09-27" @default.
- W2525555311 modified "2023-09-29" @default.
- W2525555311 title "Effective PI3K modulators for improved therapy against malignant tumors and for neuroprotection of brain damage after tumor therapy (Review)" @default.
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- W2525555311 doi "https://doi.org/10.3892/ijo.2016.3710" @default.
- W2525555311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27826621" @default.
- W2525555311 hasPublicationYear "2016" @default.
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