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• W2525601773 abstract "This study focuses on the synthesis and in vitro evaluation of magnetic nanocomposites (Fe3O4@LDH) as methotrexate (MTX) delivery system for targeted anticancer therapy. In which, the Fe3O4 nanoparticles acted as magnetically responsive carriers; the coating layer of layered double hydroxide (LDH) was used as a storehouse for MTX. The prepared Fe3O4@LDH nanocomposites exhibited a suitable size, good stability and magnetic responsibility (Ms 36.66 emu/g); MTX successfully intercalated into the LDH of Fe3O4@LDH at an entrapment rate (%) of 91.78% (the drug loading was 18.36%) by host-guest exchange process. Moreover, the release studies in vitro showed that the drug delivery system (Fe3O4@LDH-MTX) had excellent pH-sensitivity, 84.94% of MTX was released within 48 h at pH 3.5 via the co-effect of dissolution of LDH layer and ion-exchange. WST-1 assays in cancer cells (MCF-7 and HepG2) and normal cells (HUVEC) demonstrated that Fe3O4@LDH-MTX exhibited high anticancer activity while low toxicity to normal cells, and also the Fe3O4@LDH composites were practically non-toxic. Thus, our results revealed that Fe3O4@LDH-MTX would be a competitive candidate for targeted delivery and sustained and controlled release of MTX." @default.
• W2525601773 created "2016-10-07" @default.
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• W2525601773 date "2017-02-01" @default.
• W2525601773 modified "2023-10-14" @default.
• W2525601773 title "Synthesis and in vitro evaluation of pH-sensitive magnetic nanocomposites as methotrexate delivery system for targeted cancer therapy" @default.
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• W2525601773 doi "https://doi.org/10.1016/j.msec.2016.09.084" @default.
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