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- W2525626375 abstract "P update on anti-CD137 Mab and Trastuzumab stimulation of natural killer cells with an anti-CD137 antibody enhances the efficacy of Trastuzumab, Cetuximab, and Rituximab in HER2-expressing breast cancer, EGFR+ head and neck cancer, and CD20+ lymphoma. My focus is on NK cells and translational research work that led from an initial in vitro observation to Phase 1 clinical studies. The starting observation was that primary human NK cells in the presence of a CD20-positive cell line and rituximab for 24 h upregulated CD137 (4-1BB) at their cell surface, and this upregulation was dependent on effective ADCC. The same observation was made with trastuzumab and cetuximab in the presence of HER-positive and EGFR-positive tumors, respectively. Using an agonistic anti-CD137 antibody, we demonstrate that triggering CD137 on NK cells enhanced the antitumor activity of rituximab, trastuzumab and cetuximab in vitro and in vivo. I will present various additional means to enhance ADCC by blocking inhibitory signals, such as CD47 on macrophages, IL-15 on monocytes or DCs, KIR or PD-1 on NK cells." @default.
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- W2525626375 date "2015-10-15" @default.
- W2525626375 modified "2023-09-24" @default.
- W2525626375 title "Palm tocotrienols inhibit proliferation of murine mammary cancer cells, enhance immune response and induce expression of IL-24 mRNA" @default.
- W2525626375 hasPublicationYear "2015" @default.
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