FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2525702246> ?p ?o ?g. }

• W2525702246 endingPage "1138" @default.
• W2525702246 startingPage "1126" @default.
• W2525702246 abstract "It is observed that upregulation of DNMT3B enzyme in some cancers, including colon cancer, could lead to silencing of tumor suppressor genes. MiR-339 and miR-766 have been predicted to target 3'UTR of DNMT3B gene. Luciferase reporter assay validated that individual and co-transfection of miR-766 and miR-339 into the HEK293T cell reduced luciferase activity to 26% ± 0.41%, 43% ± 0.42 and 64% ± 0.52%, respectively, compared to the control (P < 0.05). Furthermore, transduction of miR-339 and miR-766 expressing viruses into colon cancer cell lines (SW480 and HCT116) decreased DNMT3B expression (1.5, 3-fold) and (3, 4-fold), respectively. In addition, DNA methylation of some tumor suppressor genes decreased. Expression of these genes such as SFRP1 (2 and 1.6-fold), SFRP2 (0.07 and 4-fold), WIF1 (0.05 and 4-fold), and DKK2 (2 and 4-fold) increased in SW-339 and SW-766 cell lines; besides, expression increments for these genes in HCT-339 and HCT-766 cell lines were (2.8, 4-fold), (0.005, 1.5-fold), (1.7 and 3-fold) and (0.04, 1.7-fold), respectively. Also, while in SW-766, cell proliferation reduced to 2.8% and 21.7% after 24 and 48 hours, respectively, SW-339 showed no reduced proliferation. Meanwhile, HCT-766 and HCT-339 showed (3.5%, 12.8%) and (18.8%, 33.9%) reduced proliferation after 24 and 48 hours, respectively. Finally, targeting DNMT3B by these miRs, decreased methylation of tumor suppressor genes such as SFRP1, SFRP2, WIF1 and DKK2 in the mentioned cell lines, and returned the expression of these tumor suppressor genes which can contribute to lethal effect on colon cancer cells and reducing tumorigenicity of these cells." @default.
• W2525702246 created "2016-10-07" @default.
• W2525702246 creator A5017121246 @default.
• W2525702246 creator A5038516179 @default.
• W2525702246 creator A5055158419 @default.
• W2525702246 creator A5057060526 @default.
• W2525702246 creator A5059939668 @default.
• W2525702246 creator A5063148488 @default.
• W2525702246 creator A5088377096 @default.
• W2525702246 date "2016-09-26" @default.
• W2525702246 modified "2023-10-12" @default.
• W2525702246 title "MiR-339 and especially miR-766 reactivate the expression of tumor suppressor genes in colorectal cancer cell lines through DNA methyltransferase 3B gene inhibition" @default.
• W2525702246 cites W1525943439 @default.
• W2525702246 cites W1601459316 @default.
• W2525702246 cites W1966530104 @default.
• W2525702246 cites W1977577913 @default.
• W2525702246 cites W1977821118 @default.
• W2525702246 cites W1979413046 @default.
• W2525702246 cites W1997431917 @default.
• W2525702246 cites W2001505418 @default.
• W2525702246 cites W2004298061 @default.
• W2525702246 cites W2006504425 @default.
• W2525702246 cites W2006797972 @default.
• W2525702246 cites W2020767030 @default.
• W2525702246 cites W2020829192 @default.
• W2525702246 cites W2026570544 @default.
• W2525702246 cites W2030166934 @default.
• W2525702246 cites W2031581570 @default.
• W2525702246 cites W2032741659 @default.
• W2525702246 cites W2034325228 @default.
• W2525702246 cites W2039876499 @default.
• W2525702246 cites W2050869737 @default.
• W2525702246 cites W2060439771 @default.
• W2525702246 cites W2064871082 @default.
• W2525702246 cites W2070484728 @default.
• W2525702246 cites W2076334656 @default.
• W2525702246 cites W2087064738 @default.
• W2525702246 cites W2096139566 @default.
• W2525702246 cites W2099900128 @default.
• W2525702246 cites W2100545040 @default.
• W2525702246 cites W2103177465 @default.
• W2525702246 cites W2106695011 @default.
• W2525702246 cites W2116548195 @default.
• W2525702246 cites W2121288523 @default.
• W2525702246 cites W2124955721 @default.
• W2525702246 cites W2128761506 @default.
• W2525702246 cites W2130439102 @default.
• W2525702246 cites W2131474316 @default.
• W2525702246 cites W2132889907 @default.
• W2525702246 cites W2139406307 @default.
• W2525702246 cites W2144027697 @default.
• W2525702246 cites W2154634442 @default.
• W2525702246 cites W2154891376 @default.
• W2525702246 cites W2155524568 @default.
• W2525702246 cites W2158630016 @default.
• W2525702246 cites W2159325140 @default.
• W2525702246 cites W2171552768 @default.
• W2525702246 doi "https://doi.org/10.1080/15384047.2016.1235657" @default.
• W2525702246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5137492" @default.
• W2525702246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27668319" @default.
• W2525702246 hasPublicationYear "2016" @default.
• W2525702246 type Work @default.
• W2525702246 sameAs 2525702246 @default.
• W2525702246 citedByCount "38" @default.
• W2525702246 countsByYear W25257022462017 @default.
• W2525702246 countsByYear W25257022462018 @default.
• W2525702246 countsByYear W25257022462019 @default.
• W2525702246 countsByYear W25257022462020 @default.
• W2525702246 countsByYear W25257022462021 @default.
• W2525702246 countsByYear W25257022462022 @default.
• W2525702246 countsByYear W25257022462023 @default.
• W2525702246 crossrefType "journal-article" @default.
• W2525702246 hasAuthorship W2525702246A5017121246 @default.
• W2525702246 hasAuthorship W2525702246A5038516179 @default.
• W2525702246 hasAuthorship W2525702246A5055158419 @default.
• W2525702246 hasAuthorship W2525702246A5057060526 @default.
• W2525702246 hasAuthorship W2525702246A5059939668 @default.
• W2525702246 hasAuthorship W2525702246A5063148488 @default.
• W2525702246 hasAuthorship W2525702246A5088377096 @default.
• W2525702246 hasBestOaLocation W25257022461 @default.
• W2525702246 hasConcept C104317684 @default.
• W2525702246 hasConcept C119056186 @default.
• W2525702246 hasConcept C121608353 @default.
• W2525702246 hasConcept C150194340 @default.
• W2525702246 hasConcept C153911025 @default.
• W2525702246 hasConcept C175211621 @default.
• W2525702246 hasConcept C190727270 @default.
• W2525702246 hasConcept C2777142704 @default.
• W2525702246 hasConcept C2778264664 @default.
• W2525702246 hasConcept C33288867 @default.
• W2525702246 hasConcept C502942594 @default.
• W2525702246 hasConcept C526805850 @default.
• W2525702246 hasConcept C54009773 @default.
• W2525702246 hasConcept C54355233 @default.
• W2525702246 hasConcept C555283112 @default.
• W2525702246 hasConcept C62112901 @default.
• W2525702246 hasConcept C81885089 @default.
• W2525702246 hasConcept C86803240 @default.

• next