Matches in SemOpenAlex for { <https://semopenalex.org/work/W2525724943> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2525724943 endingPage "143" @default.
- W2525724943 startingPage "141" @default.
- W2525724943 abstract "Interactions between the HDAC6 inhibitor ricolinostat (ACY1215) and the irreversible proteasome inhibitor Carfilzomib (CFZ) were examined in non-Hodgkin9s lymphoma models, including diffuse large B-cell (DLBCL), mantle cell (MCL) and double-hit lymphoma cells. Marked in vitro synergism was observed in multiple cell types associated with activation of cellular stress pathways (e.g., JNK1/2, ERK1/2, and p38) accompanied by increases in DNA damage (γH2A.X), G2M arrest, and the pronounced induction of mitochondrial injury and apoptosis. Combination treatment with CFZ and ricolinostat increased reactive oxygen species (ROS), while the antioxidant TBAP attenuated DNA damage, JNK activation, and cell death. Similar interactions occurred in bortezomib-resistant and double-hit DLBCL, MCL, and primary DLBCL cells, but not in normal CD34+ cells. However, ricolinostat did not potentiate inhibition of chymotryptic activity by CFZ. shRNA knock-down of JNK1 (but not MEK1/2), or pharmacologic inhibition of p38, significantly reduced CFZ/ricolinostat lethality, indicating a functional contribution of these stress pathways to apoptosis. Combined exposure to CFZ and ricolinostat also markedly down-regulated the cargo-loading protein HR23B. Moreover, HR23B knock-down significantly increased CFZ- and ricolinostat-mediated lethality, suggesting a role for this event in cell death. Finally, combined in vivo treatment with CFZ and ricolinostat was well tolerated and significantly suppressed tumor growth and increased survival in an MCL xenograft model. Collectively, these findings indicate that CFZ and ricolinostat interact synergistically in NHL cells through multiple stress-related mechanisms, and suggest that this strategy warrants further consideration in NHL." @default.
- W2525724943 created "2016-10-07" @default.
- W2525724943 creator A5072420825 @default.
- W2525724943 date "1966-03-01" @default.
- W2525724943 modified "2023-09-26" @default.
- W2525724943 title "N. SUMMARY OF DISCUSSION AND COMMENTARY" @default.
- W2525724943 hasPublicationYear "1966" @default.
- W2525724943 type Work @default.
- W2525724943 sameAs 2525724943 @default.
- W2525724943 citedByCount "0" @default.
- W2525724943 crossrefType "journal-article" @default.
- W2525724943 hasAuthorship W2525724943A5072420825 @default.
- W2525724943 hasConcept C104317684 @default.
- W2525724943 hasConcept C105580179 @default.
- W2525724943 hasConcept C143425029 @default.
- W2525724943 hasConcept C149364088 @default.
- W2525724943 hasConcept C185592680 @default.
- W2525724943 hasConcept C190283241 @default.
- W2525724943 hasConcept C203014093 @default.
- W2525724943 hasConcept C2776364478 @default.
- W2525724943 hasConcept C2777478702 @default.
- W2525724943 hasConcept C2778367456 @default.
- W2525724943 hasConcept C2779638656 @default.
- W2525724943 hasConcept C2780108899 @default.
- W2525724943 hasConcept C31573885 @default.
- W2525724943 hasConcept C502942594 @default.
- W2525724943 hasConcept C51551487 @default.
- W2525724943 hasConcept C552990157 @default.
- W2525724943 hasConcept C55493867 @default.
- W2525724943 hasConcept C57074206 @default.
- W2525724943 hasConcept C62478195 @default.
- W2525724943 hasConcept C86803240 @default.
- W2525724943 hasConcept C95444343 @default.
- W2525724943 hasConceptScore W2525724943C104317684 @default.
- W2525724943 hasConceptScore W2525724943C105580179 @default.
- W2525724943 hasConceptScore W2525724943C143425029 @default.
- W2525724943 hasConceptScore W2525724943C149364088 @default.
- W2525724943 hasConceptScore W2525724943C185592680 @default.
- W2525724943 hasConceptScore W2525724943C190283241 @default.
- W2525724943 hasConceptScore W2525724943C203014093 @default.
- W2525724943 hasConceptScore W2525724943C2776364478 @default.
- W2525724943 hasConceptScore W2525724943C2777478702 @default.
- W2525724943 hasConceptScore W2525724943C2778367456 @default.
- W2525724943 hasConceptScore W2525724943C2779638656 @default.
- W2525724943 hasConceptScore W2525724943C2780108899 @default.
- W2525724943 hasConceptScore W2525724943C31573885 @default.
- W2525724943 hasConceptScore W2525724943C502942594 @default.
- W2525724943 hasConceptScore W2525724943C51551487 @default.
- W2525724943 hasConceptScore W2525724943C552990157 @default.
- W2525724943 hasConceptScore W2525724943C55493867 @default.
- W2525724943 hasConceptScore W2525724943C57074206 @default.
- W2525724943 hasConceptScore W2525724943C62478195 @default.
- W2525724943 hasConceptScore W2525724943C86803240 @default.
- W2525724943 hasConceptScore W2525724943C95444343 @default.
- W2525724943 hasIssue "1" @default.
- W2525724943 hasLocation W25257249431 @default.
- W2525724943 hasOpenAccess W2525724943 @default.
- W2525724943 hasPrimaryLocation W25257249431 @default.
- W2525724943 hasRelatedWork W103874930 @default.
- W2525724943 hasRelatedWork W2023286508 @default.
- W2525724943 hasRelatedWork W2031726846 @default.
- W2525724943 hasRelatedWork W2047542386 @default.
- W2525724943 hasRelatedWork W2060550030 @default.
- W2525724943 hasRelatedWork W2133590787 @default.
- W2525724943 hasRelatedWork W2552277272 @default.
- W2525724943 hasRelatedWork W2587042212 @default.
- W2525724943 hasRelatedWork W2587572697 @default.
- W2525724943 hasRelatedWork W2588736843 @default.
- W2525724943 hasRelatedWork W2605481135 @default.
- W2525724943 hasRelatedWork W2611566504 @default.
- W2525724943 hasRelatedWork W2624396871 @default.
- W2525724943 hasRelatedWork W2766917114 @default.
- W2525724943 hasRelatedWork W2967362211 @default.
- W2525724943 hasRelatedWork W2979399235 @default.
- W2525724943 hasRelatedWork W2979457211 @default.
- W2525724943 hasRelatedWork W2979615158 @default.
- W2525724943 hasRelatedWork W2979820519 @default.
- W2525724943 hasRelatedWork W3131858778 @default.
- W2525724943 hasVolume "18" @default.
- W2525724943 isParatext "false" @default.
- W2525724943 isRetracted "false" @default.
- W2525724943 magId "2525724943" @default.
- W2525724943 workType "article" @default.