FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2525819627> ?p ?o ?g. }

• W2525819627 abstract "Transcriptional activation of the budding yeast CLNl and CLN2 genes during the late GI phase of the cell cycle has been attributed to a positive feedback loop, wherein the transcription of both genes is stimulated by the accumulation of their protein products. We demonstrate that in cycling cells CLN2 does not play a role in determining the timing of its own transcriptional activation. First, we show that CLN3 alone is sufficient to maximally activate CLN2 transcription. Cells that lack functional CLNl and CLN2 genes activate the CLN2 promoter with the same kinetics and at the same size as cells in which all three CLN genes are functional. In addition, CLN2 transcription is activated with similar kinetics in cells that have CLN2 as their only functional CLN gene and in CLN-deficient cells. Promoter analysis shows that CLN3-dependent activation of CLN2 transcription is directed primarily through the previously identified UASl region although another cis-acting region, UAS2, also can contribute to CLN2 activation under some conditions. The ability to activate transcription of CLN2 is not a unique property of CLN3 because ectopically expressed CLN2 can both activate the endogenous CLN2 promoter and induce Start. We propose that failure of the endogenous CLN2 gene to contribute significantly to activation of its own transcription results from its relative effectiveness at inducing Start, cell cycle progression and, subsequently, inactivation of CLN2 expression." @default.
• W2525819627 created "2016-10-07" @default.
• W2525819627 creator A5019832653 @default.
• W2525819627 date "1995-01-01" @default.
• W2525819627 modified "2023-09-27" @default.
• W2525819627 title "CLN3, not positive feedback, the timing of CLN2 transcrip in cycling cells determ tion" @default.
• W2525819627 cites W144129310 @default.
• W2525819627 cites W1530194480 @default.
• W2525819627 cites W1537782690 @default.
• W2525819627 cites W1547033864 @default.
• W2525819627 cites W1602727746 @default.
• W2525819627 cites W169216998 @default.
• W2525819627 cites W172411893 @default.
• W2525819627 cites W1759539608 @default.
• W2525819627 cites W1798548477 @default.
• W2525819627 cites W1871042223 @default.
• W2525819627 cites W1923453853 @default.
• W2525819627 cites W1967724361 @default.
• W2525819627 cites W1970783685 @default.
• W2525819627 cites W1973122477 @default.
• W2525819627 cites W1973221130 @default.
• W2525819627 cites W1973635919 @default.
• W2525819627 cites W1974905046 @default.
• W2525819627 cites W1987682724 @default.
• W2525819627 cites W1987907353 @default.
• W2525819627 cites W2009837683 @default.
• W2525819627 cites W2015498847 @default.
• W2525819627 cites W2020679691 @default.
• W2525819627 cites W2042591463 @default.
• W2525819627 cites W2043038579 @default.
• W2525819627 cites W2045737218 @default.
• W2525819627 cites W2062319807 @default.
• W2525819627 cites W2062814087 @default.
• W2525819627 cites W2064153193 @default.
• W2525819627 cites W2064249717 @default.
• W2525819627 cites W2064324413 @default.
• W2525819627 cites W2067082256 @default.
• W2525819627 cites W2068681052 @default.
• W2525819627 cites W2074126694 @default.
• W2525819627 cites W2075227844 @default.
• W2525819627 cites W2088639926 @default.
• W2525819627 cites W2094923559 @default.
• W2525819627 cites W2095571979 @default.
• W2525819627 cites W2097330051 @default.
• W2525819627 cites W2123632489 @default.
• W2525819627 cites W2140660011 @default.
• W2525819627 cites W2141653943 @default.
• W2525819627 cites W2164963113 @default.
• W2525819627 cites W2199878503 @default.
• W2525819627 cites W2261308396 @default.
• W2525819627 cites W2397944365 @default.
• W2525819627 cites W2400628512 @default.
• W2525819627 hasPublicationYear "1995" @default.
• W2525819627 type Work @default.
• W2525819627 sameAs 2525819627 @default.
• W2525819627 citedByCount "0" @default.
• W2525819627 crossrefType "journal-article" @default.
• W2525819627 hasAuthorship W2525819627A5019832653 @default.
• W2525819627 hasConcept C101762097 @default.
• W2525819627 hasConcept C104317684 @default.
• W2525819627 hasConcept C138885662 @default.
• W2525819627 hasConcept C150194340 @default.
• W2525819627 hasConcept C179926584 @default.
• W2525819627 hasConcept C27153228 @default.
• W2525819627 hasConcept C29537977 @default.
• W2525819627 hasConcept C41895202 @default.
• W2525819627 hasConcept C54355233 @default.
• W2525819627 hasConcept C86339819 @default.
• W2525819627 hasConcept C86803240 @default.
• W2525819627 hasConcept C95444343 @default.
• W2525819627 hasConceptScore W2525819627C101762097 @default.
• W2525819627 hasConceptScore W2525819627C104317684 @default.
• W2525819627 hasConceptScore W2525819627C138885662 @default.
• W2525819627 hasConceptScore W2525819627C150194340 @default.
• W2525819627 hasConceptScore W2525819627C179926584 @default.
• W2525819627 hasConceptScore W2525819627C27153228 @default.
• W2525819627 hasConceptScore W2525819627C29537977 @default.
• W2525819627 hasConceptScore W2525819627C41895202 @default.
• W2525819627 hasConceptScore W2525819627C54355233 @default.
• W2525819627 hasConceptScore W2525819627C86339819 @default.
• W2525819627 hasConceptScore W2525819627C86803240 @default.
• W2525819627 hasConceptScore W2525819627C95444343 @default.
• W2525819627 hasLocation W25258196271 @default.
• W2525819627 hasOpenAccess W2525819627 @default.
• W2525819627 hasPrimaryLocation W25258196271 @default.
• W2525819627 hasRelatedWork W1884388113 @default.
• W2525819627 hasRelatedWork W1885706271 @default.
• W2525819627 hasRelatedWork W1889276318 @default.
• W2525819627 hasRelatedWork W2005964372 @default.
• W2525819627 hasRelatedWork W2006545082 @default.
• W2525819627 hasRelatedWork W2047606638 @default.
• W2525819627 hasRelatedWork W2068681052 @default.
• W2525819627 hasRelatedWork W2118455199 @default.
• W2525819627 hasRelatedWork W2130229976 @default.
• W2525819627 hasRelatedWork W2133037637 @default.
• W2525819627 hasRelatedWork W2134651489 @default.
• W2525819627 hasRelatedWork W2152245125 @default.
• W2525819627 hasRelatedWork W2165733908 @default.
• W2525819627 hasRelatedWork W2170314995 @default.
• W2525819627 hasRelatedWork W2188398831 @default.

• next