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- W2525864706 abstract "Mammalian oocytes grow within ovarian follicles in which the oocyte is coupled to surrounding granulosa cells by gap junctions. We report here that small growing oocytes isolated from mouse preantral follicles are incapable of recovering from an experimentally-induced acidosis, and that oocytes acquire the ability to manage acid loads during growth by activating Na+/H+ exchange. In contrast, granulosa cells from similar preantral follicles possess substantial Na+/H+ exchange which can correct acidosis, which is attributable to simultaneous action of two Na+/H+ Exchanger isoforms; NHE1 and NHE3. Granulosa cells were also found to possess a V-type H+-ATPase which drives acidosis recovery when Na+/H+ exchange is inactivated. By monitoring intracellular pH (pHi) in small follicle-enclosed oocytes we found that the oocyte has access to each of these acidosis-correcting activities, such that small follicle-enclosed oocytes readily recovery from acidosis in a manner resembling granulosa cells. However, oocytes are unable to access these activities if gap-junction communication within the follicle is inhibited. Together these experiments show that gap junctions allow granulosa cells to control oocyte pHi in the acid range until the oocyte acquires the ability to carry out its own homeostatis, and reveal that granulosa cells have been amply equipped to carry out this function. (poster)" @default.
- W2525864706 created "2016-10-07" @default.
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- W2525864706 date "2007-07-01" @default.
- W2525864706 modified "2023-10-16" @default.
- W2525864706 title "GRANULOSA CELLS ASSIST THE GROWING MOUSE OOCYTE IN MANAGING ACIDOSIS VIA SEVERAL MECHANISMS" @default.
- W2525864706 doi "https://doi.org/10.1093/biolreprod/77.s1.92c" @default.
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