Matches in SemOpenAlex for { <https://semopenalex.org/work/W2525869884> ?p ?o ?g. }
- W2525869884 endingPage "1616" @default.
- W2525869884 startingPage "1616" @default.
- W2525869884 abstract "Microfluidics-based drug-screening systems have enabled efficient and high-throughput drug screening, but their routine uses in ordinary labs are limited due to the complexity involved in device fabrication and system setup. In this work, we report an easy-to-use and low-cost arbitrarily accessible 3D microfluidic device that can be easily adopted by various labs to perform combinatorial assays for high-throughput drug screening. The device is capable of precisely performing automatic and simultaneous reagent loading and aliquoting tasks and performing multistep assays with arbitrary sequences. The device is not intended to compete with other microfluidic technologies regarding ultra-low reaction volume. Instead, its freedom from tubing or pumping systems and easy operation makes it an ideal platform for routine high-throughput drug screening outside traditional microfluidic labs. The functionality and quantitative reliability of the 3D microfluidic device were demonstrated with a histone acetyltransferase-based drug-screening assay using the recombinant Plasmodium falciparum GCN5 enzyme, benchmarked with a traditional microtiter plate-based method. This arbitrarily accessible, multistep capable, low-cost, and easy-to-use device can be widely adopted in various combinatorial assays beyond high-throughput drug screening." @default.
- W2525869884 created "2016-10-07" @default.
- W2525869884 creator A5005484398 @default.
- W2525869884 creator A5006909259 @default.
- W2525869884 creator A5018284299 @default.
- W2525869884 creator A5026268139 @default.
- W2525869884 creator A5044817441 @default.
- W2525869884 creator A5055361395 @default.
- W2525869884 creator A5059383206 @default.
- W2525869884 date "2016-09-29" @default.
- W2525869884 modified "2023-09-30" @default.
- W2525869884 title "Arbitrarily Accessible 3D Microfluidic Device for Combinatorial High-Throughput Drug Screening" @default.
- W2525869884 cites W1946122328 @default.
- W2525869884 cites W1969435013 @default.
- W2525869884 cites W1969503178 @default.
- W2525869884 cites W1969710059 @default.
- W2525869884 cites W1973965902 @default.
- W2525869884 cites W1974598486 @default.
- W2525869884 cites W1975581000 @default.
- W2525869884 cites W1980221373 @default.
- W2525869884 cites W1987772374 @default.
- W2525869884 cites W1991001144 @default.
- W2525869884 cites W1991146785 @default.
- W2525869884 cites W1999848733 @default.
- W2525869884 cites W2001091497 @default.
- W2525869884 cites W2002869829 @default.
- W2525869884 cites W2009635288 @default.
- W2525869884 cites W2011043571 @default.
- W2525869884 cites W2017544508 @default.
- W2525869884 cites W2018722291 @default.
- W2525869884 cites W2019239417 @default.
- W2525869884 cites W2032039115 @default.
- W2525869884 cites W2035560688 @default.
- W2525869884 cites W2037384545 @default.
- W2525869884 cites W2042912875 @default.
- W2525869884 cites W2044159910 @default.
- W2525869884 cites W2062409563 @default.
- W2525869884 cites W2066740260 @default.
- W2525869884 cites W2071311642 @default.
- W2525869884 cites W208508301 @default.
- W2525869884 cites W2086019689 @default.
- W2525869884 cites W2086428332 @default.
- W2525869884 cites W2089704822 @default.
- W2525869884 cites W2093655203 @default.
- W2525869884 cites W2094409580 @default.
- W2525869884 cites W2097548398 @default.
- W2525869884 cites W2097660548 @default.
- W2525869884 cites W2098999080 @default.
- W2525869884 cites W2102155970 @default.
- W2525869884 cites W2103062889 @default.
- W2525869884 cites W2104645521 @default.
- W2525869884 cites W2117179092 @default.
- W2525869884 cites W2150583187 @default.
- W2525869884 cites W2169521790 @default.
- W2525869884 cites W2175894202 @default.
- W2525869884 cites W2281981908 @default.
- W2525869884 cites W2319572124 @default.
- W2525869884 cites W2325509233 @default.
- W2525869884 cites W2428054575 @default.
- W2525869884 cites W4229609981 @default.
- W2525869884 cites W4249742884 @default.
- W2525869884 doi "https://doi.org/10.3390/s16101616" @default.
- W2525869884 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5087404" @default.
- W2525869884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27690055" @default.
- W2525869884 hasPublicationYear "2016" @default.
- W2525869884 type Work @default.
- W2525869884 sameAs 2525869884 @default.
- W2525869884 citedByCount "18" @default.
- W2525869884 countsByYear W25258698842017 @default.
- W2525869884 countsByYear W25258698842018 @default.
- W2525869884 countsByYear W25258698842019 @default.
- W2525869884 countsByYear W25258698842020 @default.
- W2525869884 countsByYear W25258698842021 @default.
- W2525869884 countsByYear W25258698842022 @default.
- W2525869884 countsByYear W25258698842023 @default.
- W2525869884 crossrefType "journal-article" @default.
- W2525869884 hasAuthorship W2525869884A5005484398 @default.
- W2525869884 hasAuthorship W2525869884A5006909259 @default.
- W2525869884 hasAuthorship W2525869884A5018284299 @default.
- W2525869884 hasAuthorship W2525869884A5026268139 @default.
- W2525869884 hasAuthorship W2525869884A5044817441 @default.
- W2525869884 hasAuthorship W2525869884A5055361395 @default.
- W2525869884 hasAuthorship W2525869884A5059383206 @default.
- W2525869884 hasBestOaLocation W25258698841 @default.
- W2525869884 hasConcept C121332964 @default.
- W2525869884 hasConcept C157764524 @default.
- W2525869884 hasConcept C163258240 @default.
- W2525869884 hasConcept C171250308 @default.
- W2525869884 hasConcept C185592680 @default.
- W2525869884 hasConcept C192562407 @default.
- W2525869884 hasConcept C2778810118 @default.
- W2525869884 hasConcept C41008148 @default.
- W2525869884 hasConcept C43214815 @default.
- W2525869884 hasConcept C43617362 @default.
- W2525869884 hasConcept C51323132 @default.
- W2525869884 hasConcept C555944384 @default.
- W2525869884 hasConcept C60644358 @default.
- W2525869884 hasConcept C62520636 @default.