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• W2525949986 abstract "Abstract Experimental huts are part of the WHO process for testing and evaluation of Insecticide Treated Nets (ITN) in semi-field conditions. Experimental Hut Trials (EHTs) mostly focus on two main indicators (i.e. mortality and blood feeding reduction) that serve as efficacy criteria to obtain WHO interim recommendation. However, several other outputs that rely on counts of vectors collected in the huts are neglected although they can give useful information about vectors behavior and personal protection provided by ITNs. In particular, EHTs allow to measure the deterrent effect and personal protection of ITNs. To provide a better assessment of ITNs efficacy, we performed a retrospective analysis of the deterrence and the personal protection against malaria transmission for 12 unwashed and 13 washed ITNs evaluated through EHTs conducted in West Africa. A significant deterrent effect was shown for six of the 12 unwashed ITNs tested. When washed 20 times, only three ITNs had significant deterrent effect (Rate Ratios (RR)<1; p<0.05) and three showed an apparent “attractiveness” (RR>1; p<0.01). When compared to the untreated net, all unwashed ITNs showed lower number of blood-fed Anopheles indicating a significant personal protection (RR<1, p<0.05). However, when washed 20 times, three ITNs that were found to be attractive did not significantly reduced human-vector contact (p>0.05). Current WHO efficacy criteria do not sufficiently take into account the deterrence effect of ITNs. Moreover the deterrence variability is rarely discussed in EHT's reports. Our findings highlighted the long range effect (deterrent or attractive) of ITNs that may have significant consequences for personal/community protection against malaria transmission. Indicators measuring the deterrence should be further considered for the evaluation of ITNs." @default.
• W2525949986 created "2016-10-07" @default.
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• W2525949986 date "2016-09-22" @default.
• W2525949986 modified "2023-10-18" @default.
• W2525949986 title "Remote effect of Insecticide-treated nets and the personal protection against malaria mosquito bites" @default.
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• W2525949986 doi "https://doi.org/10.1101/073718" @default.
• W2525949986 hasPublicationYear "2016" @default.
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