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- W2525960017 abstract "P A2 (PLA2) is a universal toxi enzyme present in all the snake venoms causing painful inflammation. PLA 2 forms 60% of the proteins of the venom, hence, preventing PLA2 action is of great importance, first breakthrough came from that, Turmerin: A water soluble antioxidant protein from Turmeric (Curcuma longa Linn) prevents its inflammatory action. Snake venom also induces DNA damage and the damage as assessed by us was much more than be accounted for venom alone. So, we looked for a factor that, may be acting in tandem with the venom in causing apoptosis, such a factor was secreted at 15 minutes after by human lymphocyte treatment with venom PLA2 which can came 44% DNA damage by itself. This factor was purified by several steps was found to be of 6 kDa peptide and its profile was established by using several exocytosis inhibitors. We surmised that, this death peptide signal was of membrane origin. The sequence and homology showed that, it has 40 amino acids MSILPCKNVS IWVIKDTAAS DKEVVLGSDR AIKFLYLATG showing that, it is an apoptosis inducing factor." @default.
- W2525960017 created "2016-10-07" @default.
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- W2525960017 date "2014-12-01" @default.
- W2525960017 modified "2023-09-25" @default.
- W2525960017 title "A novel secreted death peptide from Cobra Venom Phospholipase A2 treated human lymphocytes" @default.
- W2525960017 hasPublicationYear "2014" @default.
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