FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2525982599> ?p ?o ?g. }

• W2525982599 abstract "Accumulating evidence has confirmed that miR-196a plays a critical role in tumorigenesis and tumor progression in a variety of cancers. It has been demonstrated that miR-196a is highly up-regulated in laryngeal cancer by miRNA profiling analysis. However, the functional mechanism of miR-196a in laryngeal cancer remains unclear. This study aims to explore the mechanism of miR-196a in laryngeal cancer.In the present study, we conducted qPCR analysis of miR-196a expression in human laryngeal cancer and showed that miR-196a was overexpressed in tumor-derived samples and laryngeal cancer cell lines compared with matched normal controls. Further functional analysis of miR-196a demonstrated that the inhibition of miR-196a could inhibit laryngeal cell-cycle progression and proliferation in vitro. Luciferase reporter assay and western blot confirmed that miR-196a directly targeted p27kip1. Moreover, in order to investigate whether miR-196a regulated cell growth in laryngeal cancer cells by targeting p27kip1, rescue studies were performed in laryngeal cancer cells.Results showed that overexpression of p27kip1 rescue decreased cell proliferation caused by miR-196a inhibitors. A negative relation between miR-196a and p27kip1 expression in laryngeal cancer tissues were also noted by further analyses.The present study showed that miR-196a was upregulated in laryngeal cancer and promoted cell proliferation by downregulating p27kip1 in laryngeal cancer. However, further studies are needed to verify this finding." @default.
• W2525982599 created "2016-10-07" @default.
• W2525982599 creator A5031508846 @default.
• W2525982599 creator A5044544424 @default.
• W2525982599 creator A5086709648 @default.
• W2525982599 date "2016-09-27" @default.
• W2525982599 modified "2023-09-27" @default.
• W2525982599 title "Upregulation of MiR-196a promotes cell proliferation by downregulating p27kip1 in laryngeal cancer" @default.
• W2525982599 cites W144423133 @default.
• W2525982599 cites W1939696168 @default.
• W2525982599 cites W1975437957 @default.
• W2525982599 cites W1978601487 @default.
• W2525982599 cites W1986915398 @default.
• W2525982599 cites W2002995168 @default.
• W2525982599 cites W2004339436 @default.
• W2525982599 cites W2006874274 @default.
• W2525982599 cites W2010040408 @default.
• W2525982599 cites W2015066175 @default.
• W2525982599 cites W2069465596 @default.
• W2525982599 cites W2076483508 @default.
• W2525982599 cites W2079251691 @default.
• W2525982599 cites W2081684895 @default.
• W2525982599 cites W2106258494 @default.
• W2525982599 cites W2116711648 @default.
• W2525982599 cites W2125301608 @default.
• W2525982599 cites W2131596261 @default.
• W2525982599 cites W2164194749 @default.
• W2525982599 cites W2165755332 @default.
• W2525982599 cites W2165801731 @default.
• W2525982599 cites W2180702776 @default.
• W2525982599 cites W2222767430 @default.
• W2525982599 cites W2235523043 @default.
• W2525982599 cites W2270571558 @default.
• W2525982599 cites W2295032943 @default.
• W2525982599 cites W2302279046 @default.
• W2525982599 cites W2402849622 @default.
• W2525982599 cites W2597632520 @default.
• W2525982599 doi "https://doi.org/10.1186/s40659-016-0100-9" @default.
• W2525982599 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5039793" @default.
• W2525982599 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27678369" @default.
• W2525982599 hasPublicationYear "2016" @default.
• W2525982599 type Work @default.
• W2525982599 sameAs 2525982599 @default.
• W2525982599 citedByCount "18" @default.
• W2525982599 countsByYear W25259825992017 @default.
• W2525982599 countsByYear W25259825992018 @default.
• W2525982599 countsByYear W25259825992019 @default.
• W2525982599 countsByYear W25259825992020 @default.
• W2525982599 countsByYear W25259825992021 @default.
• W2525982599 countsByYear W25259825992022 @default.
• W2525982599 countsByYear W25259825992023 @default.
• W2525982599 crossrefType "journal-article" @default.
• W2525982599 hasAuthorship W2525982599A5031508846 @default.
• W2525982599 hasAuthorship W2525982599A5044544424 @default.
• W2525982599 hasAuthorship W2525982599A5086709648 @default.
• W2525982599 hasBestOaLocation W25259825991 @default.
• W2525982599 hasConcept C104317684 @default.
• W2525982599 hasConcept C121608353 @default.
• W2525982599 hasConcept C126322002 @default.
• W2525982599 hasConcept C127561419 @default.
• W2525982599 hasConcept C145059251 @default.
• W2525982599 hasConcept C2910049883 @default.
• W2525982599 hasConcept C502942594 @default.
• W2525982599 hasConcept C54355233 @default.
• W2525982599 hasConcept C555283112 @default.
• W2525982599 hasConcept C62112901 @default.
• W2525982599 hasConcept C71924100 @default.
• W2525982599 hasConcept C86803240 @default.
• W2525982599 hasConcept C96232424 @default.
• W2525982599 hasConceptScore W2525982599C104317684 @default.
• W2525982599 hasConceptScore W2525982599C121608353 @default.
• W2525982599 hasConceptScore W2525982599C126322002 @default.
• W2525982599 hasConceptScore W2525982599C127561419 @default.
• W2525982599 hasConceptScore W2525982599C145059251 @default.
• W2525982599 hasConceptScore W2525982599C2910049883 @default.
• W2525982599 hasConceptScore W2525982599C502942594 @default.
• W2525982599 hasConceptScore W2525982599C54355233 @default.
• W2525982599 hasConceptScore W2525982599C555283112 @default.
• W2525982599 hasConceptScore W2525982599C62112901 @default.
• W2525982599 hasConceptScore W2525982599C71924100 @default.
• W2525982599 hasConceptScore W2525982599C86803240 @default.
• W2525982599 hasConceptScore W2525982599C96232424 @default.
• W2525982599 hasIssue "1" @default.
• W2525982599 hasLocation W25259825991 @default.
• W2525982599 hasLocation W25259825992 @default.
• W2525982599 hasLocation W25259825993 @default.
• W2525982599 hasLocation W25259825994 @default.
• W2525982599 hasLocation W25259825995 @default.
• W2525982599 hasOpenAccess W2525982599 @default.
• W2525982599 hasPrimaryLocation W25259825991 @default.
• W2525982599 hasRelatedWork W2033672302 @default.
• W2525982599 hasRelatedWork W2604068828 @default.
• W2525982599 hasRelatedWork W2626794881 @default.
• W2525982599 hasRelatedWork W2740221126 @default.
• W2525982599 hasRelatedWork W2797473499 @default.
• W2525982599 hasRelatedWork W2972806461 @default.
• W2525982599 hasRelatedWork W2998722864 @default.
• W2525982599 hasRelatedWork W3025716972 @default.
• W2525982599 hasRelatedWork W3150490778 @default.
• W2525982599 hasRelatedWork W4246363308 @default.

• next