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• W2525991645 abstract "Cisplatin was the first of the platinum drugs. Second-generation platinum derivativewas carboplatin that its efficacy in the treatment of many malignancies is equal tocisplatin, and its toxicity profile is more favorable. Here we report on a 50-year-oldwoman with a history of cervix cancer who developed a severe hypersensitivity reaction(HSR) to carboplatin. She was admitted to the emergency department (ED) withshortness of breath, tachypnea, restless, agitation, and lethargy. On arrival, the patientwas hemodynamically unstable; we initiated treatment immediately with hydration,oxygen therapy with mask, hydrocortisone, midazolam, and adrenalin. After 1 hour, BPand O2 sat improved to 100/70 mm Hg and 92% respectively, but there was not anysignificant improvement in tachycardia as well as tachypnea and she was still lethargicand agitated. Her symptoms improved gradually after 18 hours of admission. She wasdischarged after 36 hours. HSRs to cisplatin and carboplatin can be potentially lifethreatening. The symptoms can range from a mild rash to severe anaphylaxis. Doctorsshould be aware of these reactions, determine appropriate treatment, and know thecross-reactivity among these drugs." @default.
• W2525991645 created "2016-10-07" @default.
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• W2525991645 date "2015-09-15" @default.
• W2525991645 modified "2023-09-24" @default.
• W2525991645 title "Hypersensitivity and cross-reactivity to cisplatin and carboplatin" @default.
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• W2525991645 doi "https://doi.org/10.15171/jept.2016.09" @default.
• W2525991645 hasPublicationYear "2015" @default.
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