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• W2526004889 abstract "DXA is the optimal method to assess bone mineral density (BMD), but it is often unavailable in clinical practice due to inaccessibility and prohibitive cost. Instead, many physicians prefer to evaluate BMD via quantitative ultrasound (QUS). QUS measurements have been shown to predict future fractures as accurately as central measurements of the spine or femur in postmenopausal women, but little research has demonstrated the efficacy of these measurements in children. QUS may prove to be a useful radiation free method for studying bone density accrual in children. PURPOSE: To develop prediction equations for total body (TB), femoral neck (FN) and lumbar spine (LU) BMD in children using QUS estimated BMD values and general descriptive characteristics. METHODS: QUS and DXA data were collected from 220 healthy children (114 boys, 106 girls, mean age 13.75 + 3.11 years, range 7.87–17.99 years) participating in the Fels Longitudinal Study at the Lifespan Health Research Center. DXA scans of the TB, LU, and FN were collected and QUS was assessed twice bilaterally in each child. An average of the values from the left calcaneous was subsequently analyzed. Stature and weight were collected and BMI was calculated. Descriptive statistics and Pearson's correlations were computed, and stepwise multiple regression analyses determined the influence of QUS, age, sex, weight, stature, BMI, on BMD of the TB, FN, and LU and the most parsimonious model for predicting each. RESULTS: All predictor variables were significantly correlated with each of the outcomes except sex was only significantly correlated with LU BMD. QUS, age, and weight were the best predictors, appearing in each model. QUS estimated BMD alone accounted for less than a fifth of the variance in each of TB, LU, and FN BMD (R2 = .18, R2 = .16, R2 = .18, respectively). TB BMD was best predicted by QUS, age, stature, and weight (R2 = .72); LU BMD was best predicted by QUS, sex, age, and weight (R2 = .73); and FN BMD was best predicted by QUS, age, sex, and weight (R2 = .69). BMI added value as a predictive variable, but its effect was colinear with weight and it was deleted from the final models. CONCLUSIONS: QUS was an effective predictor of TB, LU, and FN BMD in children when used in these models. This allows for a low cost, widely available, assessment of bone density in children with no radiation exposure. Those children identified with low BMD can be advised to take steps to increase bone accrual before adulthood." @default.
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• W2526004889 date "2006-05-01" @default.
• W2526004889 modified "2023-09-25" @default.
• W2526004889 title "Prediction of Bone Mineral Density from Calcaneal Ultrasound in Adolescents" @default.
• W2526004889 doi "https://doi.org/10.1249/00005768-200605001-03092" @default.
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