FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2526076709> ?p ?o ?g. }

• W2526076709 endingPage "499" @default.
• W2526076709 startingPage "491" @default.
• W2526076709 abstract "Pretraumatic cigarette smoke (CS) exposure aggravates posttraumatic acute lung injury (ALI). Cystathionine-γ-lyase (CSE) protects against ALI and CS exposure-induced chronic obstructive lung disease (COPD). Therefore, we tested the hypothesis whether genetic CSE knockout (CSE) would aggravate posttraumatic ALI after CS exposure. After 3 to 4 weeks of CS exposure, anesthetized wild-type (WT) and CSE mice underwent blunt chest trauma, surgical instrumentation and 4 h of lung-protective mechanical ventilation. We measured hemodynamics, lung mechanics, gas exchange, metabolism, and acid-base status together with blood and tissue cytokine and chemokine levels, tissue expression of mediator proteins, parameters of oxidative and nitrosative stress, and histology. CSE mice without CS exposure showed higher cytokine and chemokine levels, and this was further enhanced by CS exposure, particularly in males. CS exposure in WT mice aggravated posttraumatic alveolar membrane thickening, dystelectasis, and inflammatory cell accumulation, which was associated with higher thoracopulmonary compliance. Pretraumatic CS exposure in CSE mice produced a similar response, except for less alveolar membrane thickening, most likely due to lung hyperinflation. CS-exposed WT mice showed the most pronounced metabolic acidosis, while CS exposure in CSE mice resulted in the lowest blood glucose levels. Urinary output and anesthesia rate were highest in male CS-exposed CSE animals. In conclusion, in murine acute-on-chronic pulmonary disease, CSE knockout aggravated posttraumatic inflammation, which was further worsened upon pretraumatic CS exposure, and this effect was particularly pronounced in males. Hence, maintaining CSE expression is critically important for stress adaptation during ALI and CS-induced COPD, most likely in a gender-dependent manner." @default.
• W2526076709 created "2016-10-07" @default.
• W2526076709 creator A5002730004 @default.
• W2526076709 creator A5012712888 @default.
• W2526076709 creator A5015146765 @default.
• W2526076709 creator A5021170936 @default.
• W2526076709 creator A5024003678 @default.
• W2526076709 creator A5024719790 @default.
• W2526076709 creator A5030242411 @default.
• W2526076709 creator A5033389583 @default.
• W2526076709 creator A5043861758 @default.
• W2526076709 creator A5050944660 @default.
• W2526076709 creator A5052262395 @default.
• W2526076709 creator A5056536609 @default.
• W2526076709 creator A5058049602 @default.
• W2526076709 creator A5059324975 @default.
• W2526076709 creator A5068224616 @default.
• W2526076709 creator A5072113176 @default.
• W2526076709 creator A5089170315 @default.
• W2526076709 creator A5090295630 @default.
• W2526076709 date "2017-04-01" @default.
• W2526076709 modified "2023-10-16" @default.
• W2526076709 title "The Role of Cystathionine-γ-Lyase In Blunt Chest Trauma in Cigarette Smoke Exposed Mice" @default.
• W2526076709 cites W1482429511 @default.
• W2526076709 cites W1901437714 @default.
• W2526076709 cites W1964155163 @default.
• W2526076709 cites W1967981332 @default.
• W2526076709 cites W1975167982 @default.
• W2526076709 cites W1975278498 @default.
• W2526076709 cites W1985232927 @default.
• W2526076709 cites W1990819855 @default.
• W2526076709 cites W1999669162 @default.
• W2526076709 cites W2003868744 @default.
• W2526076709 cites W2023535191 @default.
• W2526076709 cites W2026695480 @default.
• W2526076709 cites W2033283725 @default.
• W2526076709 cites W2033798933 @default.
• W2526076709 cites W2034550176 @default.
• W2526076709 cites W2041456315 @default.
• W2526076709 cites W2044708956 @default.
• W2526076709 cites W2052748040 @default.
• W2526076709 cites W2054064167 @default.
• W2526076709 cites W2061627667 @default.
• W2526076709 cites W2068453689 @default.
• W2526076709 cites W2069227638 @default.
• W2526076709 cites W2071236203 @default.
• W2526076709 cites W2084940755 @default.
• W2526076709 cites W2089790562 @default.
• W2526076709 cites W2104564480 @default.
• W2526076709 cites W2104716397 @default.
• W2526076709 cites W2120309958 @default.
• W2526076709 cites W2149700046 @default.
• W2526076709 cites W2163240112 @default.
• W2526076709 cites W2461258175 @default.
• W2526076709 doi "https://doi.org/10.1097/shk.0000000000000746" @default.
• W2526076709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27685807" @default.
• W2526076709 hasPublicationYear "2017" @default.
• W2526076709 type Work @default.
• W2526076709 sameAs 2526076709 @default.
• W2526076709 citedByCount "14" @default.
• W2526076709 countsByYear W25260767092017 @default.
• W2526076709 countsByYear W25260767092018 @default.
• W2526076709 countsByYear W25260767092019 @default.
• W2526076709 countsByYear W25260767092020 @default.
• W2526076709 countsByYear W25260767092021 @default.
• W2526076709 countsByYear W25260767092022 @default.
• W2526076709 crossrefType "journal-article" @default.
• W2526076709 hasAuthorship W2526076709A5002730004 @default.
• W2526076709 hasAuthorship W2526076709A5012712888 @default.
• W2526076709 hasAuthorship W2526076709A5015146765 @default.
• W2526076709 hasAuthorship W2526076709A5021170936 @default.
• W2526076709 hasAuthorship W2526076709A5024003678 @default.
• W2526076709 hasAuthorship W2526076709A5024719790 @default.
• W2526076709 hasAuthorship W2526076709A5030242411 @default.
• W2526076709 hasAuthorship W2526076709A5033389583 @default.
• W2526076709 hasAuthorship W2526076709A5043861758 @default.
• W2526076709 hasAuthorship W2526076709A5050944660 @default.
• W2526076709 hasAuthorship W2526076709A5052262395 @default.
• W2526076709 hasAuthorship W2526076709A5056536609 @default.
• W2526076709 hasAuthorship W2526076709A5058049602 @default.
• W2526076709 hasAuthorship W2526076709A5059324975 @default.
• W2526076709 hasAuthorship W2526076709A5068224616 @default.
• W2526076709 hasAuthorship W2526076709A5072113176 @default.
• W2526076709 hasAuthorship W2526076709A5089170315 @default.
• W2526076709 hasAuthorship W2526076709A5090295630 @default.
• W2526076709 hasConcept C126322002 @default.
• W2526076709 hasConcept C142724271 @default.
• W2526076709 hasConcept C203014093 @default.
• W2526076709 hasConcept C2776151105 @default.
• W2526076709 hasConcept C2776780178 @default.
• W2526076709 hasConcept C2776914184 @default.
• W2526076709 hasConcept C2777714996 @default.
• W2526076709 hasConcept C2777961210 @default.
• W2526076709 hasConcept C71924100 @default.
• W2526076709 hasConceptScore W2526076709C126322002 @default.
• W2526076709 hasConceptScore W2526076709C142724271 @default.
• W2526076709 hasConceptScore W2526076709C203014093 @default.
• W2526076709 hasConceptScore W2526076709C2776151105 @default.

• next