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- W2526295073 abstract "Prenatal diagnosis of adrenal tumor is quite rare. We present 3 cases of fetuses with cystic masses in adrenal region detected by ultrasound - histologically proven neuroblastoma and two cases concluded as prenatal adrenal hemorrhage. The diagnosis of retroperitoneal mass was made in the 3rd trimester. There was no regression observed in prenatal findings, in one case we recorded another contralateral lesion 4 weeks after the initial diagnosis. Magnetic resonance imaging assessed the tumor in accordance with the ultrasound examination. Associated malformations or metastatic spread were not detected. All the patients delivered naturally in term. After the delivery, laboratory tests for adrenal hormones and their metabolites with ultrasound examination were performed. In one case early surgery - adrenalectomy - was indicated based on the imaging methods with the final diagnosis of neuroblastoma. In the case of the other two newborns conservative management without biopsy was selected. Ultrasound examination after 2 and 4 weeks proved signs of regression. These cases were concluded as adrenal hemorrhage. In the last years we have noticed an increase in abundance of prenatal findings of retroperitoneal masses. Absolute majority of them is diagnosed within the 3rd trimester. Sonographical findings of these tumors are variable - from cystic to solid lesions. Distinguishing between adrenal hemorrhage and neuroblastoma is very difficult. Magnetic resonance imaging can increase specificity, but not by a significant margin. Examining maternal blood for catecholamines or their metabolites brings no benefit. Conservative management of postnatal care should be preferred in cases where the mass is limited to adrenal gland and the newborn is asymptomatic, because vast majority of congenital adrenal tumors - both hemorrhages and neuroblastomas - regress spontaneously. Careful observation is needed. Prenatally detected adrenal tumors including neuroblastomas have in most cases good prognosis, even when dissemination is found. Supported by grant CZ.2.16/3.1.00/24022" @default.
- W2526295073 created "2016-10-07" @default.
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- W2526295073 date "2014-09-01" @default.
- W2526295073 modified "2023-09-23" @default.
- W2526295073 title "P24.08: Prenatal diagnosis of 3 adrenal tumors and the postnatal outcome" @default.
- W2526295073 doi "https://doi.org/10.1002/uog.14468" @default.
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