FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2526338590> ?p ?o ?g. }

• W2526338590 endingPage "355" @default.
• W2526338590 startingPage "346" @default.
• W2526338590 abstract "Central nervous system infiltration and relapse are poorly understood in childhood acute lymphoblastic leukemia. We examined the role of zeta-chain-associated protein kinase 70 in preclinical models of central nervous system leukemia and performed correlative studies in patients. Zeta-chain-associated protein kinase 70 expression in acute lymphoblastic leukemia cells was modulated using short hairpin ribonucleic acid-mediated knockdown or ectopic expression. We show that zeta-chain-associated protein kinase 70 regulates CCR7/CXCR4 via activation of extracellular signal-regulated kinases. High expression of zeta-chain-associated protein kinase 70 in acute lymphoblastic leukemia cells resulted in a higher proportion of central nervous system leukemia in xenografts as compared to zeta-chain-associated protein kinase 70 low expressing counterparts. High zeta-chain-associated protein kinase 70 also enhanced the migration potential towards CCL19/CXCL12 gradients in vitro CCR7 blockade almost abrogated homing of acute lymphoblastic leukemia cells to the central nervous system in xenografts. In 130 B-cell precursor acute lymphoblastic leukemia and 117 T-cell acute lymphoblastic leukemia patients, zeta-chain-associated protein kinase 70 and CCR7/CXCR4 expression levels were significantly correlated. Zeta-chain-associated protein kinase 70 expression correlated with central nervous system disease in B-cell precursor acute lymphoblastic leukemia, and CCR7/CXCR4 correlated with central nervous system involvement in T-cell acute lymphoblastic leukemia patients. In multivariate analysis, zeta-chain-associated protein kinase 70 expression levels in the upper third and fourth quartiles were associated with central nervous system involvement in B-cell precursor acute lymphoblastic leukemia (odds ratio=7.48, 95% confidence interval, 2.06-27.17; odds ratio=6.86, 95% confidence interval, 1.86-25.26, respectively). CCR7 expression in the upper fourth quartile correlated with central nervous system positivity in T-cell acute lymphoblastic leukemia (odds ratio=11.00, 95% confidence interval, 2.00-60.62). We propose zeta-chain-associated protein kinase 70, CCR7 and CXCR4 as markers of central nervous system infiltration in acute lymphoblastic leukemia warranting prospective investigation." @default.
• W2526338590 created "2016-10-07" @default.
• W2526338590 creator A5012603847 @default.
• W2526338590 creator A5020812442 @default.
• W2526338590 creator A5039478360 @default.
• W2526338590 creator A5039583258 @default.
• W2526338590 creator A5040156837 @default.
• W2526338590 creator A5044244016 @default.
• W2526338590 creator A5050786337 @default.
• W2526338590 creator A5067297108 @default.
• W2526338590 creator A5084831240 @default.
• W2526338590 creator A5090678844 @default.
• W2526338590 creator A5091832008 @default.
• W2526338590 date "2016-09-29" @default.
• W2526338590 modified "2023-10-12" @default.
• W2526338590 title "The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system" @default.
• W2526338590 cites W1485852181 @default.
• W2526338590 cites W1906100218 @default.
• W2526338590 cites W1916983144 @default.
• W2526338590 cites W1964250079 @default.
• W2526338590 cites W1968174927 @default.
• W2526338590 cites W1973220007 @default.
• W2526338590 cites W1984046622 @default.
• W2526338590 cites W2002108583 @default.
• W2526338590 cites W2007511032 @default.
• W2526338590 cites W2016833582 @default.
• W2526338590 cites W2020622102 @default.
• W2526338590 cites W2028881763 @default.
• W2526338590 cites W2031192472 @default.
• W2526338590 cites W2033315156 @default.
• W2526338590 cites W2039378498 @default.
• W2526338590 cites W2040691054 @default.
• W2526338590 cites W2043389011 @default.
• W2526338590 cites W2046928857 @default.
• W2526338590 cites W2047403065 @default.
• W2526338590 cites W2048654561 @default.
• W2526338590 cites W2062073560 @default.
• W2526338590 cites W2068835290 @default.
• W2526338590 cites W2078262569 @default.
• W2526338590 cites W2086341831 @default.
• W2526338590 cites W2086943873 @default.
• W2526338590 cites W2087111337 @default.
• W2526338590 cites W2096093613 @default.
• W2526338590 cites W2098735224 @default.
• W2526338590 cites W2099540110 @default.
• W2526338590 cites W2102677365 @default.
• W2526338590 cites W2107792217 @default.
• W2526338590 cites W2117173232 @default.
• W2526338590 cites W2129141528 @default.
• W2526338590 cites W2132079316 @default.
• W2526338590 cites W2138426987 @default.
• W2526338590 cites W2140644116 @default.
• W2526338590 cites W2141297227 @default.
• W2526338590 cites W2144889904 @default.
• W2526338590 cites W2146173960 @default.
• W2526338590 cites W2150144939 @default.
• W2526338590 cites W2154022654 @default.
• W2526338590 cites W2154724678 @default.
• W2526338590 cites W2155908269 @default.
• W2526338590 cites W2164732415 @default.
• W2526338590 cites W2243988080 @default.
• W2526338590 cites W2266192831 @default.
• W2526338590 cites W2300927433 @default.
• W2526338590 cites W2337451127 @default.
• W2526338590 cites W754919562 @default.
• W2526338590 doi "https://doi.org/10.3324/haematol.2016.147744" @default.
• W2526338590 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5286942" @default.
• W2526338590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27686375" @default.
• W2526338590 hasPublicationYear "2016" @default.
• W2526338590 type Work @default.
• W2526338590 sameAs 2526338590 @default.
• W2526338590 citedByCount "42" @default.
• W2526338590 countsByYear W25263385902017 @default.
• W2526338590 countsByYear W25263385902018 @default.
• W2526338590 countsByYear W25263385902019 @default.
• W2526338590 countsByYear W25263385902020 @default.
• W2526338590 countsByYear W25263385902021 @default.
• W2526338590 countsByYear W25263385902022 @default.
• W2526338590 countsByYear W25263385902023 @default.
• W2526338590 crossrefType "journal-article" @default.
• W2526338590 hasAuthorship W2526338590A5012603847 @default.
• W2526338590 hasAuthorship W2526338590A5020812442 @default.
• W2526338590 hasAuthorship W2526338590A5039478360 @default.
• W2526338590 hasAuthorship W2526338590A5039583258 @default.
• W2526338590 hasAuthorship W2526338590A5040156837 @default.
• W2526338590 hasAuthorship W2526338590A5044244016 @default.
• W2526338590 hasAuthorship W2526338590A5050786337 @default.
• W2526338590 hasAuthorship W2526338590A5067297108 @default.
• W2526338590 hasAuthorship W2526338590A5084831240 @default.
• W2526338590 hasAuthorship W2526338590A5090678844 @default.
• W2526338590 hasAuthorship W2526338590A5091832008 @default.
• W2526338590 hasBestOaLocation W25263385901 @default.
• W2526338590 hasConcept C203014093 @default.
• W2526338590 hasConcept C41650920 @default.
• W2526338590 hasConcept C42362537 @default.
• W2526338590 hasConcept C502942594 @default.
• W2526338590 hasConcept C62478195 @default.
• W2526338590 hasConcept C71924100 @default.

• next