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- W2526447978 abstract "ABSTRACTObesity-related inflammation promotes cancer development. Tissue resident macrophages affect tumor progression and the tumor micro-environment favors polarization into alternatively activated macrophages (M2) that facilitate tumor invasiveness. Here, we dissected the role of western diet-induced NASH in inducing macrophage polarization in a carcinogen initiated model of hepatocellular carcinoma (HCC). Adult C57BL/6 male mice received diethyl nitrosamine (DEN) followed by 24 weeks of high fat–high cholesterol–high sugar diet (HF-HC-HSD). We assessed liver MRI and histology, serum ALT, AFP, liver triglycerides, and cytokines. Macrophage polarization was determined by IL-12/TNFα (M1) and CD163/CD206 (M2) expression using flow cytometry. Role of hif-1α-induced IL-10 was dissected in hepatocyte specific hif-1αKO and hif-1αdPA (over-expression) mice. The western diet-induced features of NASH and accelerated HCC development after carcinogen exposure. Liver fibrosis and serum AFP were significantly increa..." @default.
- W2526447978 created "2016-10-07" @default.
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- W2526447978 date "2016-09-26" @default.
- W2526447978 modified "2023-10-12" @default.
- W2526447978 title "Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1<b>α</b>induced IL-10" @default.
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- W2526447978 doi "https://doi.org/10.1080/2162402x.2016.1221557" @default.
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