Matches in SemOpenAlex for { <https://semopenalex.org/work/W2526479644> ?p ?o ?g. }
- W2526479644 endingPage "947" @default.
- W2526479644 startingPage "936" @default.
- W2526479644 abstract "Abstract The major histocompatibility complex I (MHC-1) presents antigenic peptides to tumor-specific CD8+ T cells. The regulation of MHC-I by kinases is largely unstudied, even though many patients with cancer are receiving therapeutic kinase inhibitors. Regulators of cell-surface HLA amounts were discovered using a pooled human kinome shRNA interference–based approach. Hits scoring highly were subsequently validated by additional RNAi and pharmacologic inhibitors. MAP2K1 (MEK), EGFR, and RET were validated as negative regulators of MHC-I expression and antigen presentation machinery in multiple cancer types, acting through an ERK output–dependent mechanism; the pathways responsible for increased MHC-I upon kinase inhibition were mapped. Activated MAPK signaling in mouse tumors in vivo suppressed components of MHC-I and the antigen presentation machinery. Pharmacologic inhibition of MAPK signaling also led to improved peptide/MHC target recognition and killing by T cells and TCR-mimic antibodies. Druggable kinases may thus serve as immediately applicable targets for modulating immunotherapy for many diseases. Cancer Immunol Res; 4(11); 936–47. ©2016 AACR." @default.
- W2526479644 created "2016-10-07" @default.
- W2526479644 creator A5002951130 @default.
- W2526479644 creator A5006257943 @default.
- W2526479644 creator A5006680533 @default.
- W2526479644 creator A5025451142 @default.
- W2526479644 creator A5029670586 @default.
- W2526479644 creator A5032404829 @default.
- W2526479644 creator A5035010583 @default.
- W2526479644 creator A5036401196 @default.
- W2526479644 creator A5046495281 @default.
- W2526479644 creator A5054656505 @default.
- W2526479644 creator A5055435856 @default.
- W2526479644 creator A5060228803 @default.
- W2526479644 creator A5067313194 @default.
- W2526479644 creator A5072042134 @default.
- W2526479644 creator A5073815714 @default.
- W2526479644 creator A5081366346 @default.
- W2526479644 creator A5082626339 @default.
- W2526479644 creator A5086601654 @default.
- W2526479644 date "2016-10-31" @default.
- W2526479644 modified "2023-10-16" @default.
- W2526479644 title "Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells" @default.
- W2526479644 cites W1800636867 @default.
- W2526479644 cites W1949265142 @default.
- W2526479644 cites W1961692905 @default.
- W2526479644 cites W1963549191 @default.
- W2526479644 cites W1968893719 @default.
- W2526479644 cites W1973051874 @default.
- W2526479644 cites W1975887213 @default.
- W2526479644 cites W1981948896 @default.
- W2526479644 cites W1986464292 @default.
- W2526479644 cites W1990757073 @default.
- W2526479644 cites W2002214314 @default.
- W2526479644 cites W2015069573 @default.
- W2526479644 cites W2016671320 @default.
- W2526479644 cites W2018093205 @default.
- W2526479644 cites W2031203833 @default.
- W2526479644 cites W2035482294 @default.
- W2526479644 cites W2036062404 @default.
- W2526479644 cites W2044835625 @default.
- W2526479644 cites W2049553585 @default.
- W2526479644 cites W2059149312 @default.
- W2526479644 cites W2065141010 @default.
- W2526479644 cites W2066671159 @default.
- W2526479644 cites W2068116723 @default.
- W2526479644 cites W2069166009 @default.
- W2526479644 cites W2080686146 @default.
- W2526479644 cites W2088540000 @default.
- W2526479644 cites W2088615080 @default.
- W2526479644 cites W2094481139 @default.
- W2526479644 cites W2094652659 @default.
- W2526479644 cites W2097095323 @default.
- W2526479644 cites W2099044540 @default.
- W2526479644 cites W2104885590 @default.
- W2526479644 cites W2107429737 @default.
- W2526479644 cites W2113664558 @default.
- W2526479644 cites W2114671410 @default.
- W2526479644 cites W2115160431 @default.
- W2526479644 cites W2123918574 @default.
- W2526479644 cites W2126181231 @default.
- W2526479644 cites W2129676200 @default.
- W2526479644 cites W2134799914 @default.
- W2526479644 cites W2136474966 @default.
- W2526479644 cites W2136799969 @default.
- W2526479644 cites W2144242764 @default.
- W2526479644 cites W2147210428 @default.
- W2526479644 cites W2289851792 @default.
- W2526479644 cites W2298618221 @default.
- W2526479644 cites W2324450935 @default.
- W2526479644 cites W2472473226 @default.
- W2526479644 cites W2560367415 @default.
- W2526479644 cites W62176468 @default.
- W2526479644 doi "https://doi.org/10.1158/2326-6066.cir-16-0177" @default.
- W2526479644 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5110210" @default.
- W2526479644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27680026" @default.
- W2526479644 hasPublicationYear "2016" @default.
- W2526479644 type Work @default.
- W2526479644 sameAs 2526479644 @default.
- W2526479644 citedByCount "113" @default.
- W2526479644 countsByYear W25264796442017 @default.
- W2526479644 countsByYear W25264796442018 @default.
- W2526479644 countsByYear W25264796442019 @default.
- W2526479644 countsByYear W25264796442020 @default.
- W2526479644 countsByYear W25264796442021 @default.
- W2526479644 countsByYear W25264796442022 @default.
- W2526479644 countsByYear W25264796442023 @default.
- W2526479644 crossrefType "journal-article" @default.
- W2526479644 hasAuthorship W2526479644A5002951130 @default.
- W2526479644 hasAuthorship W2526479644A5006257943 @default.
- W2526479644 hasAuthorship W2526479644A5006680533 @default.
- W2526479644 hasAuthorship W2526479644A5025451142 @default.
- W2526479644 hasAuthorship W2526479644A5029670586 @default.
- W2526479644 hasAuthorship W2526479644A5032404829 @default.
- W2526479644 hasAuthorship W2526479644A5035010583 @default.
- W2526479644 hasAuthorship W2526479644A5036401196 @default.
- W2526479644 hasAuthorship W2526479644A5046495281 @default.
- W2526479644 hasAuthorship W2526479644A5054656505 @default.