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- W2526821734 abstract "Mesothelial cells lining the pericardium generate the proepicardium (PE), the precursor cell population of the epicardium, the outer layer covering the myocardium, which is essential for its maturation and the formation of the heart valves and coronary vasculature. Two mechanisms have been proposed based on fixed samples: 1. The formation of a bridge between the PE and the ventricle. 2. The release of cyst into the pericardial cavity. However, there is no evidence from in vivo studies showing how epicardial precursor cells reach and attach to the heart. Hydrodynamic forces play a central role in organ morphogenesis. The role of blood flow in shaping the developing heart is well established, but the role of fluid forces generated in the pericardial cavity surrounding the heart is unknown. Using optical tools for real-time analysis in the zebrafish, including high-speed imaging and optical tweezing, we show that the heartbeat generates pericardiac fluid advections that drive epicardium formation. These flow forces trigger PE formation and epicardial progenitor cell release and motion. The pericardial flow also influences the site of PE cell adhesion to the myocardium. We found primary cilia protruding into the pericardial cavity from PE and pericardial cells that could be mediating the mechanotransduction of fluid forces. Additionally, we identified a novel mesothelial sources of epicardial precursors and show that precursor release and adhesion occur both through pericardiac fluid advections and through direct contact with the myocardium. Thus, two hydrodynamic forces couple cardiac development with function: first, blood flow inside the heart, and second, the pericardial fluid advections outside the heart identified here. This pericardiac fluid flow is essential for epicardium formation and represents the first example of hydrodynamic flow forces controlling organogenesis through an action on mesothelial cells." @default.
- W2526821734 created "2016-10-07" @default.
- W2526821734 creator A5043965856 @default.
- W2526821734 date "2016-04-27" @default.
- W2526821734 modified "2023-09-23" @default.
- W2526821734 title "Dissecting the role of heartbeat-driven pericardiac fluid forces on epicardium morphogenesis through in vivo imaging in the zebrafish." @default.
- W2526821734 hasPublicationYear "2016" @default.
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